Cited 28 times in
Transcriptional activation of SHP by PPAR-γ in liver
DC Field | Value | Language |
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dc.contributor.author | 고유경 | - |
dc.contributor.author | 권슬기 | - |
dc.contributor.author | 김경섭 | - |
dc.contributor.author | 김태현 | - |
dc.contributor.author | 김하일 | - |
dc.contributor.author | 안용호 | - |
dc.contributor.author | 임승순 | - |
dc.date.accessioned | 2014-12-21T16:26:22Z | - |
dc.date.available | 2014-12-21T16:26:22Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95695 | - |
dc.description.abstract | The mechanism of how PPARγ decrease gluconeogenic gene expressions in liver is still unclear. Since PPARγ is a transcriptional activator, it requires a mediator to decrease the transcription of gluconeogenic genes. Recently, SHP has been shown to mediate the bile acid-dependent down regulation of gluconeogenic gene expression in liver. This led us to explore the possibility that SHP may mediate the antigluconeogenic effect of PPARγ. In the present study, we have identified and characterized the presence of functional PPRE in human SHP promoter. We show the binding of PPARγ/RXRα heterodimer to the PPRE and increased SHP expression by rosiglitazone in primary rat hepatocytes. Taken together with the previous reports about the function of SHP on gluconeogenesis, our results indicate that SHP can mediate the acute antigluconeogenic effect of PPARγ. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 301~306 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Transcriptional activation of SHP by PPAR-γ in liver | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Ha-il Kim | - |
dc.contributor.googleauthor | Yoo-Kyung Koh | - |
dc.contributor.googleauthor | Tae-Hyun Kim | - |
dc.contributor.googleauthor | Sool-Ki Kwon | - |
dc.contributor.googleauthor | Seung-Soon Im | - |
dc.contributor.googleauthor | Hueng-Sik Choi | - |
dc.contributor.googleauthor | Kyung-Sup Kim | - |
dc.contributor.googleauthor | Yong-Ho Ahn | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.05.171 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00132 | - |
dc.contributor.localId | A00224 | - |
dc.contributor.localId | A00297 | - |
dc.contributor.localId | A01092 | - |
dc.contributor.localId | A02249 | - |
dc.contributor.localId | A03376 | - |
dc.contributor.localId | A01081 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X07010984 | - |
dc.contributor.alternativeName | Koh, Yoo Kyung | - |
dc.contributor.alternativeName | Kwon, Sool Ki | - |
dc.contributor.alternativeName | Kim, Kyung Sup | - |
dc.contributor.alternativeName | Kim, Tae Hyun | - |
dc.contributor.alternativeName | Kim, Ha Il | - |
dc.contributor.alternativeName | Ahn, Yong Ho | - |
dc.contributor.alternativeName | Im, Seung Soon | - |
dc.contributor.affiliatedAuthor | Koh, Yoo Kyung | - |
dc.contributor.affiliatedAuthor | Kwon, Sool Ki | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sup | - |
dc.contributor.affiliatedAuthor | Kim, Ha Il | - |
dc.contributor.affiliatedAuthor | Ahn, Yong Ho | - |
dc.contributor.affiliatedAuthor | Im, Seung Soon | - |
dc.contributor.affiliatedAuthor | Kim, Tae Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 360 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 301 | - |
dc.citation.endPage | 306 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.360(2) : 301-306, 2007 | - |
dc.identifier.rimsid | 45029 | - |
dc.type.rims | ART | - |
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