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Reversine stimulates adipocyte differentiation and downregulates Akt and p70s6k signaling pathways in 3T3-L1 cells

Authors
 Yong Kee Kim  ;  Hye-Young Choi  ;  Su-Nam Kim  ;  Sahng Wook Park  ;  Jeung-Whan Han  ;  Hoi Young Lee  ;  Dong-Won Kang  ;  Dong-Wan Seo  ;  Woojung Lee  ;  Nam Hyun Kim 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.358(2) : 553-558, 2007 
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN
 0006-291X 
Issue Date
2007
Abstract
In this study, we investigate the ability of reversine to stimulate adipocyte differentiation and its effect on cellular signaling pathways associated with adipocyte differentiation. Our data show that reversine treatment of 3T3-L1 cells under differentiation conditions synergistically enhances adipocyte differentiation and the expression of adipogenic marker genes such as aP2, PPAR-γ, resistin, C/EBPα, and adiponectin. In parallel, reversine treatment leads to a selective downregulation of Akt and p70s6k signaling pathways, but not the ERK pathway. Furthermore, reversine stimulation of adipocyte differentiation seems to be quite different from troglitazone’s action, because reversine treatment does not induce the transcriptional activation of PPAR-γ and troglitazone does not affect the Akt and p70s6k signaling pathways. Taken together, our data clearly demonstrate the ability of reversine to stimulate adipocyte differentiation, which is independent of the Akt and p70s6k signaling pathways.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X07009035
DOI
10.1016/j.bbrc.2007.04.165
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95692
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