Cited 49 times in
Reversine stimulates adipocyte differentiation and downregulates Akt and p70s6k signaling pathways in 3T3-L1 cells
DC Field | Value | Language |
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dc.contributor.author | 박상욱 | - |
dc.date.accessioned | 2014-12-21T16:26:17Z | - |
dc.date.available | 2014-12-21T16:26:17Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95692 | - |
dc.description.abstract | In this study, we investigate the ability of reversine to stimulate adipocyte differentiation and its effect on cellular signaling pathways associated with adipocyte differentiation. Our data show that reversine treatment of 3T3-L1 cells under differentiation conditions synergistically enhances adipocyte differentiation and the expression of adipogenic marker genes such as aP2, PPAR-γ, resistin, C/EBPα, and adiponectin. In parallel, reversine treatment leads to a selective downregulation of Akt and p70s6k signaling pathways, but not the ERK pathway. Furthermore, reversine stimulation of adipocyte differentiation seems to be quite different from troglitazone’s action, because reversine treatment does not induce the transcriptional activation of PPAR-γ and troglitazone does not affect the Akt and p70s6k signaling pathways. Taken together, our data clearly demonstrate the ability of reversine to stimulate adipocyte differentiation, which is independent of the Akt and p70s6k signaling pathways. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 553~558 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Reversine stimulates adipocyte differentiation and downregulates Akt and p70s6k signaling pathways in 3T3-L1 cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Yong Kee Kim | - |
dc.contributor.googleauthor | Hye-Young Choi | - |
dc.contributor.googleauthor | Su-Nam Kim | - |
dc.contributor.googleauthor | Sahng Wook Park | - |
dc.contributor.googleauthor | Jeung-Whan Han | - |
dc.contributor.googleauthor | Hoi Young Lee | - |
dc.contributor.googleauthor | Dong-Won Kang | - |
dc.contributor.googleauthor | Dong-Wan Seo | - |
dc.contributor.googleauthor | Woojung Lee | - |
dc.contributor.googleauthor | Nam Hyun Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.04.165 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01487 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X07009035 | - |
dc.contributor.alternativeName | Park, Sahng Wook | - |
dc.contributor.affiliatedAuthor | Park, Sahng Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 358 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 553 | - |
dc.citation.endPage | 558 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.358(2) : 553-558, 2007 | - |
dc.identifier.rimsid | 45026 | - |
dc.type.rims | ART | - |
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