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In vivo MR Imaging of Tissue-engineered Human Mesenchymal Stem Cells Transplanted to Mouse: a Preliminary Study

DC FieldValueLanguage
dc.contributor.author서진석-
dc.contributor.author송호택-
dc.contributor.author허용민-
dc.date.accessioned2014-12-21T16:23:42Z-
dc.date.available2014-12-21T16:23:42Z-
dc.date.issued2007-
dc.identifier.issn0090-6964-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95611-
dc.description.abstractCurrent progress integrating stem cell biology and tissue engineering techniques has been invaluable to clinical applications. Prior to the application of celluar transplantation technique to patients, we need to establish techniques that can monitor their tissue biodistribution non-invasively. In this study, we proposed an imaging modality using MRI to not only monitor implanted scaffold in vivo, but also to track transplanted cells and behavior around the implant. For this purpose, human bone marrow-derived mesenchymal stem cells (hMSCs) were labeled with superparamagnetic iron oxide (Feridex) and then labeled hMSCs were cultured in a gelatin sponge used as a scaffold to support cell growth and proliferation. Histological assessment and MTT assay showed that cell labeling with MR contrast agent did not harm cell viability. Also, Feridex-labeled hMSCs showed a significant decrease in T2 signal intensity, even within the gelatin sponge in vitro. After implanting the sponge/cell complex in vivo, we could visualize cellular behavior around the implant over time using a noninvasive MRI modality and this finding was correlated with histological study, which illustrates the potential of a new approach proposed here for in vivo monitoring of implanted cell-based tissue-engineered product.-
dc.description.statementOfResponsibilityopen-
dc.format.extent101~108-
dc.relation.isPartOfANNALS OF BIOMEDICAL ENGINEERING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIn vivo MR Imaging of Tissue-engineered Human Mesenchymal Stem Cells Transplanted to Mouse: a Preliminary Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorIn Kap Ko-
dc.contributor.googleauthorHo-Taek Song-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorEun Sook Lee-
dc.contributor.googleauthorEun-Jin Cho-
dc.identifier.doi10.1007/s10439-006-9204-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01916-
dc.contributor.localIdA02080-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ00154-
dc.identifier.eissn1573-9686-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10439-006-9204-7-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.rights.accessRightsnot free-
dc.citation.volume35-
dc.citation.number1-
dc.citation.startPage101-
dc.citation.endPage108-
dc.identifier.bibliographicCitationANNALS OF BIOMEDICAL ENGINEERING, Vol.35(1) : 101-108, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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