Cited 58 times in

Evaluation of serum and urinary angiogenic factors in patients with endometriosis

Authors
 Si Hyun Cho  ;  Yoon Jin Oh  ;  Byung Seok Lee  ;  Dong Je Cho  ;  Ki Hyun Park  ;  Jae Hoon Kim  ;  Joo Hyun Park  ;  Hye Yeon Kim  ;  Anna Nam 
Citation
 AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.58(6) : 497-504, 2007 
Journal Title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN
 1046-7408 
Issue Date
2007
Abstract
PROBLEM:
The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-alpha (TNF-alpha), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis.
METHOD OF STUDY:
During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls.
RESULTS:
Serum TNF-alpha levels and urinary sFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P=0.001 and P=0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P=0.014 and P=0.015 respectively), where serum TNF-alpha levels were increased in moderate-to-severe endometriosis (P<0.001).
CONCLUSION:
The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2007.00535.x/abstract
DOI
10.1111/j.1600-0897.2007.00535.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Kim, Hye Yeon(김혜연)
Nam, An Na(남안나)
Park, Ki Hyun(박기현)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Dong Je(조동제)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95563
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links