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Differential expression of nestin in normal and pre-eclamptic human placentas

Authors
 HAN-SUNG HWANG  ;  NAM-HOON CHO  ;  YOUNG-HAN KIM  ;  YONG-WON PARK  ;  MYUNG-HWA KANG  ;  YONG-SUN MAENG 
Citation
 ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol.86(8) : 909-914, 2007 
Journal Title
 ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 
ISSN
 0001-6349 
Issue Date
2007
Abstract
BACKGROUND: Nestin is a type VI intermediate filament protein originally described in neural stem cells. Recent reports have documented nestin expression in endothelium of newly formed blood vessels and suggested its role as a marker of capacity for neovascularization and angiogenesis in endothelial cells. The aim of this study was to investigate the differential expression of nestin in normal and pre-eclamptic human placentas. METHODS: Placental tissues from 12 women with severe pre-eclampsia and 15 gestational age-matched normotensive women were collected at the time of their cesarean section. Western blot analysis for each placental tissue was performed for nestin quantification. Immunohistochemical staining was employed to localize nestin-positive cells and to investigate differential staining intensity in each placental cell. RESULTS: Nestin expression was detected in all of the normal and pre-eclamptic placental tissues by Western blotting. Compared with the normal placentas, tissues from severe pre-eclamptic placentas showed higher expression of nestin (p<0.001). Nestin immunoreactivity was localized only to endothelial cells of chorionic villi. However, mesenchymal connective tissue cells, cytotrophoblasts, syncytiotrophoblasts, and decidual cells did not reveal any specific signal for nestin. CONCLUSIONS: We suggest that the capacity for neovascularization and angiogenesis in endothelial cell is increased in pre-eclamptic placenta compared to that from normal pregnancy. Such changes may be a compensatory mechanism for the reduced maternofetal exchanges and long-lasting fetal hypoxia in pre-eclamptic pregnancy. Furthermore, these changes in endothelial cells of chorionic villi in pre-eclamptic pregnancy may give an explanation for fetal response to pre-eclamptic conditions.
Full Text
http://onlinelibrary.wiley.com/doi/10.1080/00016340701417018/abstract
DOI
10.1080/00016340701417018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Myung Hwa(강명화)
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Hwang, Han Sung(황한성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95521
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