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Acute appendicitis in young adults: low- versus standard-radiation-dose contrast-enhanced abdominal CT for diagnosis.

Authors
 So Yeon Kim  ;  Kyoung Ho Lee  ;  Kyuseok Kim  ;  Tae Yun Kim  ;  Hye Seung Lee  ;  Seung-sik Hwang  ;  Ki Jun Song  ;  Heung Sik Kang  ;  Young Hoon Kim  ;  Joong Eui Rhee 
Citation
 RADIOLOGY, Vol.260(2) : 437-445, 2011 
Journal Title
 RADIOLOGY 
ISSN
 0033-8419 
Issue Date
2011
MeSH
Adolescent ; Adult ; Appendicitis/diagnostic imaging* ; Contrast Media ; Diagnosis, Differential ; Female ; Humans ; Iohexol/analogs & derivatives ; Logistic Models ; Male ; ROC Curve ; Radiation Dosage* ; Radiographic Image Interpretation, Computer-Assisted ; Radiography, Abdominal/methods* ; Retrospective Studies ; Sensitivity and Specificity ; Statistics, Nonparametric ; Tomography, X-Ray Computed/methods*
Abstract
PURPOSE: To compare low and standard radiation doses in intravenous contrast material-enhanced abdominal computed tomography (CT) for the diagnosis of acute appendicitis in young adults. MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived informed consent. The study included 257 patients (age range, 15-40 years) who underwent CT for suspected appendicitis performed by using a low radiation dose (n = 125) or a standard radiation dose (n = 132). Receiver operating characteristic (ROC) analysis, Fisher exact tests, and Mann-Whitney U tests were used to compare the diagnosis of appendicitis and diagnostic confidence as recorded in prospective CT reports between the two groups. RESULTS: For 55 low-radiation-dose (median dose-length product, 122 mGy · cm) and 44 standard-dose (median dose-length product, 544 mGy · cm) examinations, one of two abdominal radiologists made primary reports that served as final reports. For the remaining examinations, on-call radiologists with differing levels of experience issued preliminary reports and the two abdominal radiologists then provided final reports. In the primary reports, the low- and standard-dose CT groups did not significantly differ in area under the ROC curve (0.96 vs 0.97, P = .76), sensitivity (90% [38 of 42] vs 89% [47 of 53], P > .99), or specificity (92% [76 of 83] vs 94% [74 of 79], P = .74) in the diagnosis of appendicitis. There was also no significant difference between the two groups in the confidence level when diagnosing (P = .71) or excluding (P = .20) appendicitis in the primary reports. Similar results were observed for the final reports. The two dose groups also did not significantly differ in terms of appendiceal visualization, diagnosis of appendiceal perforation, or sensitivity for alternative diagnoses. CONCLUSION: Low-dose CT may have comparable diagnostic performance to standard-dose CT for the diagnosis of appendicitis in young adults
Full Text
http://pubs.rsna.org/doi/abs/10.1148/radiol.11102247
DOI
10.1148/radiol.11102247
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95332
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