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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

Authors
 Hee Seok Yang ; Jaehoon Shin ; Byung-Soo Kim ; Chang-Sung Kim ; Gun-Il Im ; Jooyeon Park ; Jung-Youn Shin ; Suk Ho Bhang 
Citation
 Experimental and Molecular Medicine, Vol.43(11) : 622~629, 2011 
Journal Title
 Experimental and Molecular Medicine 
ISSN
 1226-3613 
Issue Date
2011
Abstract
Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PRP and HCF exerts sustained release of several growth factors contained in PRP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PRP from HCF was sustained for a longer period than those from PRP, calcium-activated PRP (C-PRP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95261
DOI
10.3858/emm.2011.43.11.070
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Periodontology
Yonsei Authors
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