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서방형 아세트아미노펜 중독 환자에 대한 고찰

Other Titles
 Extended Blood Drug Concentrations in Extended Release Formulated Acetaminophen Overdose Patients 
 범진호  ;  이누가  ;  김민정  ;  박정숙  ;  김현종  ;  정성필  ;  이한식 
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.9(2) : 71-76, 2011 
Journal Title
Journal of the Korean Society of Clinical Toxicology(대한임상독성학회지)
Issue Date
Poisoning ; Acetaminophen ; Delayed action preparations
Purpose: The Rumack-Matthew nomogram cannot be applied in managing overdose by extended release (ER) preparation acetaminophen (AAP). This study analyzed the clinical characteristics of ER preparation AAP overdose in order to develop a treatment recommendation. Methods: We retrospectively reviewed the medical records of patients presented to the emergency department as a result of AAP overdose from Jan 2008 to Dec 2010. Only those patients who ingested an ER preparation of AAP were included in the study. Their blood AAP concentrations were measured at 4 and 8 hours after ingestion. Clinical variables related to AAP intoxication were analyzed. Results: Of the total 108 AAP overdose patients identified during the 3-year period, 20 suffered specifically with ER preparation AAP overdose. The mean estimated ingestion amount was 167.5 mg/kg. Treatments including gastric lavage, activated charcoal, and N-acetyl cysteine (NAC) were performed on 10, 14, and 11 patients, respectively. Hepatotoxicity was diagnosed in only one patient who was then successfully treated with NAC. In another case, blood AAP concentration continued to increase until at least 11-hours after ingestion. Conclusion: This study suggested that blood AAP concentrations associated with ingestion of ER formulations of AAP, may increase in an extended manner. Therefore, multiple sampling and longer periods between samples assessing AAP blood concentration may be required for incidences of extended release overdose.
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Joung(김민정) ORCID logo https://orcid.org/0000-0003-1634-5209
Kim, Hyun Jong(김현종)
Rhee, Nu Ga(이누가)
Lee, Hahn Shick(이한식)
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
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