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A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritable bowel syndrome: effect on quality of life

 Choi, Chang Hwan  ;  Jo, Sun Young  ;  Park, Hyo Jin  ;  Chang, Sae Kyung  ;  Byeon, Jeong-Sik  ;  Myung, Seung-Jae 
 Journal of Clinical Gastroenterology, Vol.45(8) : 679-683, 2011 
Journal Title
 Journal of Clinical Gastroenterology 
Issue Date
Adult ; Chi-Square Distribution ; Defecation ; Double-Blind Method ; Female ; Humans ; Irritable Bowel Syndrome/microbiology ; Irritable Bowel Syndrome/physiopathology ; Irritable Bowel Syndrome/psychology ; Irritable Bowel Syndrome/therapy* ; Male ; Middle Aged ; Placebo Effect ; Probiotics/therapeutic use* ; Quality of Life* ; Republic of Korea ; Saccharomyces/growth & development* ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome
irritable bowel syndrome ; probiotics ; quality of life
BACKGROUND: Probiotics confer health benefits to the host. However, its clinical effect on irritable bowel syndrome (IBS) is controversial. AIMS: This study was aimed to evaluate the effects of Saccharomyces boulardii on quality of life (QOL) and symptoms in patients with diarrhea-predominant IBS or mixed-type IBS. METHODS: Sixty-seven patients with IBS were randomized either to receive S. boulardii at 2×10 live cells as a daily dose (n=34), or placebo (n=33) for 4 weeks. IBS-QOL was assessed at the beginning and end of the treatment phase. IBS-related symptoms, bowel movement frequency, and stool consistency were recorded on a daily basis and assessed each week. RESULTS: The overall improvement in IBS-QOL was higher in S. boulardii group than placebo (15.4% vs 7.0%; P<0.05). All eight domains of IBS-QOL were significantly improved in S. boulardii group; however, placebo group only showed improvements in dysphoria and health worry. Composite scores for IBS symptoms were significantly reduced in both groups to a similar extent. Bowel frequency and stool consistency did not change in either group. CONCLUSIONS: S. boulardii improved IBS-QOL better than placebo but was not superior for individual symptoms in patients with diarrhea-predominant IBS or mixed-type IBS.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
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