Cited 116 times in
A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritable bowel syndrome: effect on quality of life
DC Field | Value | Language |
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dc.contributor.author | 박효진 | - |
dc.date.accessioned | 2014-12-20T17:45:30Z | - |
dc.date.available | 2014-12-20T17:45:30Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0192-0790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95206 | - |
dc.description.abstract | BACKGROUND: Probiotics confer health benefits to the host. However, its clinical effect on irritable bowel syndrome (IBS) is controversial. AIMS: This study was aimed to evaluate the effects of Saccharomyces boulardii on quality of life (QOL) and symptoms in patients with diarrhea-predominant IBS or mixed-type IBS. METHODS: Sixty-seven patients with IBS were randomized either to receive S. boulardii at 2×10 live cells as a daily dose (n=34), or placebo (n=33) for 4 weeks. IBS-QOL was assessed at the beginning and end of the treatment phase. IBS-related symptoms, bowel movement frequency, and stool consistency were recorded on a daily basis and assessed each week. RESULTS: The overall improvement in IBS-QOL was higher in S. boulardii group than placebo (15.4% vs 7.0%; P<0.05). All eight domains of IBS-QOL were significantly improved in S. boulardii group; however, placebo group only showed improvements in dysphoria and health worry. Composite scores for IBS symptoms were significantly reduced in both groups to a similar extent. Bowel frequency and stool consistency did not change in either group. CONCLUSIONS: S. boulardii improved IBS-QOL better than placebo but was not superior for individual symptoms in patients with diarrhea-predominant IBS or mixed-type IBS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 679~683 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Defecation | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Irritable Bowel Syndrome/microbiology | - |
dc.subject.MESH | Irritable Bowel Syndrome/physiopathology | - |
dc.subject.MESH | Irritable Bowel Syndrome/psychology | - |
dc.subject.MESH | Irritable Bowel Syndrome/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Placebo Effect | - |
dc.subject.MESH | Probiotics/therapeutic use* | - |
dc.subject.MESH | Quality of Life* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Saccharomyces/growth & development* | - |
dc.subject.MESH | Surveys and Questionnaires | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritable bowel syndrome: effect on quality of life | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Choi, Chang Hwan | - |
dc.contributor.googleauthor | Jo, Sun Young | - |
dc.contributor.googleauthor | Park, Hyo Jin | - |
dc.contributor.googleauthor | Chang, Sae Kyung | - |
dc.contributor.googleauthor | Byeon, Jeong-Sik | - |
dc.contributor.googleauthor | Myung, Seung-Jae | - |
dc.identifier.doi | 10.1097/MCG.0b013e318204593e | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01774 | - |
dc.relation.journalcode | J01319 | - |
dc.identifier.eissn | 1539-2031 | - |
dc.identifier.pmid | 21301358 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-201109000-00006&LSLINK=80&D=ovft | - |
dc.subject.keyword | irritable bowel syndrome | - |
dc.subject.keyword | probiotics | - |
dc.subject.keyword | quality of life | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 679 | - |
dc.citation.endPage | 683 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.45(8) : 679-683, 2011 | - |
dc.identifier.rimsid | 28173 | - |
dc.type.rims | ART | - |
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