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Correlation between iodine intake and thyroid function in subjects with normal thyroid function

Authors
 Sena Hwang  ;  Eun Young Lee  ;  Woo Kyung Lee  ;  Dong Yeob Shin  ;  Eun Jig Lee 
Citation
 BIOLOGICAL TRACE ELEMENT RESEARCH, Vol.143(3) : 1393-1397, 2011 
Journal Title
BIOLOGICAL TRACE ELEMENT RESEARCH
ISSN
 0163-4984 
Issue Date
2011
MeSH
Female ; Humans ; Iodine/metabolism* ; Male ; Middle Aged ; Reference Values ; Thyroid Function Tests*
Keywords
Urine iodine ; Iodine intake
Abstract
Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone (TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = -0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels were negatively correlated with FT4 (γ = -0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid function. Population-based study will be helpful for further clarification.
Full Text
http://link.springer.com/article/10.1007%2Fs12011-011-8997-x
DOI
10.1007/s12011-011-8997-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Lee, Woo Kyung(이우경) ORCID logo https://orcid.org/0000-0002-6737-3173
Lee, Eun Young(이은영)
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Hwang, Se Na(황세나)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95102
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