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Correlation between iodine intake and thyroid function in subjects with normal thyroid function

DC Field Value Language
dc.contributor.author신동엽-
dc.contributor.author이우경-
dc.contributor.author이은영-
dc.contributor.author이은직-
dc.contributor.author황세나-
dc.date.accessioned2014-12-20T17:42:12Z-
dc.date.available2014-12-20T17:42:12Z-
dc.date.issued2011-
dc.identifier.issn0163-4984-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95102-
dc.description.abstractExcessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone (TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = -0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels were negatively correlated with FT4 (γ = -0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid function. Population-based study will be helpful for further clarification.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1393~1397-
dc.relation.isPartOfBIOLOGICAL TRACE ELEMENT RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIodine/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReference Values-
dc.subject.MESHThyroid Function Tests*-
dc.titleCorrelation between iodine intake and thyroid function in subjects with normal thyroid function-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSena Hwang-
dc.contributor.googleauthorEun Young Lee-
dc.contributor.googleauthorWoo Kyung Lee-
dc.contributor.googleauthorDong Yeob Shin-
dc.contributor.googleauthorEun Jig Lee-
dc.identifier.doi10.1007/s12011-011-8997-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02093-
dc.contributor.localIdA03050-
dc.contributor.localIdA04468-
dc.contributor.localIdA02991-
dc.contributor.localIdA03042-
dc.relation.journalcodeJ00306-
dc.identifier.eissn1559-0720-
dc.identifier.pmid21340678-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs12011-011-8997-x-
dc.subject.keywordUrine iodine-
dc.subject.keywordIodine intake-
dc.contributor.alternativeNameShin, Dong Yeob-
dc.contributor.alternativeNameLee, Woo Kyung-
dc.contributor.alternativeNameLee, Eung Young-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameHwang, Se Na-
dc.contributor.affiliatedAuthorShin, Dong Yeob-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorHwang, Se Na-
dc.contributor.affiliatedAuthorLee, Woo Kyung-
dc.contributor.affiliatedAuthorLee, Eun Young-
dc.rights.accessRightsnot free-
dc.citation.volume143-
dc.citation.number3-
dc.citation.startPage1393-
dc.citation.endPage1397-
dc.identifier.bibliographicCitationBIOLOGICAL TRACE ELEMENT RESEARCH, Vol.143(3) : 1393-1397, 2011-
dc.identifier.rimsid28095-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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