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In Vitro Antifungal Activity of Epigallocatechin 3-O-Gallate against Clinical Isolates of Dermatophytes

Authors
 Bong Joo Park  ;  Hideaki Taguchi  ;  Katsuhiko Kamei  ;  Tetsuhiro Matsuzawa  ;  Suong-Hyu Hyon  ;  Jong-Chul Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.52(3) : 535-538, 2011 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2011
MeSH
Antifungal Agents/pharmacology* ; Arthrodermataceae/drug effects* ; Arthrodermataceae/isolation & purification ; Catechin/analogs & derivatives* ; Catechin/pharmacology ; Microbial Sensitivity Tests
Keywords
Epigallocatechin 3-O-gallate ; Dermatophytes ; Microsporum canis ; Trichophyton mentagrophytes ; Trichophyton rubrum ; Susceptibility
Abstract
Previously, we reported that epigallocatechin 3-O-gallate (EGCg) has growth-inhibitory effect on clinical isolates of Candida species. In this study, we investigated the antifungal activity of EGCg and antifungal agents against thirty-five of dermatophytes clinically isolated by the international guidelines (M38-A2). All isolates exhibited good susceptibility to EGCg (MIC₅₀, 2-4 μg/mL, MIC₉₀, 4-8 μg/mL, and geometric mean (GM) MICs, 3.36-4 μg/mL) than those of fluconazole (MIC₅₀, 2-16 μg/mL, MIC₉₀, 4-32 μg/mL, and GM MICs, 3.45-25.8 μg/mL) and flucytosin (MIC₅₀, MIC₉₀, and GM MICs, >64 μg/mL), although they were less susceptible to other antifungal agents, such as amphotericin B, itraconazole, and miconazole. These activities of EGCg were approximately 4-fold higher than those of fluconazole, and were 4 to 16-fold higher than flucytosin. This result indicates that EGCg can inhibit pathogenic dermatophyte species. Therefore, we suggest that EGCg may be effectively used solely as a possible agent or combined with other antifungal agents for antifungal therapy in dermatophytosis.
Files in This Item:
T201105282.pdf Download
DOI
10.3349/ymj.2011.52.3.535
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95084
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