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Sex differences in the relationship between metabolic syndrome and pulmonary function: the 2007 Korean National Health and Nutrition Examination Survey

 Ji-Ho Choi  ;  Sunghoon Park  ;  Youn-Ho Shin  ;  Moo-Young Kim  ;  Yong-Jae Lee 
 ENDOCRINE JOURNAL, Vol.58(6) : 459-465, 2011 
Journal Title
Issue Date
Adult ; Aged ; Asian Continental Ancestry Group ; Blood Glucose ; Blood Pressure ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Forced Expiratory Volume/physiology ; Humans ; Lung/physiopathology* ; Male ; Metabolic Syndrome/physiopathology* ; Middle Aged ; Nutrition Surveys ; Republic of Korea/epidemiology ; Sex Characteristics ; Vital Capacity/physiology ; Waist Circumference
Metabolic syndrome ; Pulmonary function ; Insulin resistance ; Sex differences
Pulmonary function impairment has a connection with abdominal obesity, type 2 diabetes, and insulin resistance. Sex differences in lifestyle factors, and pulmonary structure and function may affect pulmonary function in different manners. This study focused on sex differences in the relationship of MetS and its component with pulmonary function. Among 2,614 Korean adults (1,059 men; 1,555 women), pulmonary function was measured by the percentage of predicted forced vital capacity (FVC (%)) and a ratio between forced expiratory volume in 1 second (FEV(1))/FVC. FVC (%) and FEV(1)/FVC were compared according to the presence of MetS and its components. Multiple linear regression analysis was conducted to assess the association between FVC (%), FEV(1)/FVC and clinical variables. We found sex differences in the relationship of MetS and its components with pulmonary function. FVC (%) was significantly lower in subjects with MetS than in those without MetS in both men and women, and FEV(1)/FVC was lower in subjects with MetS only in women. Among components of MetS, waist circumference, blood pressure and fasting plasma glucose, and HDL-cholesterol were independently related to FVC (%) in men, whereas waist circumference was significantly associated with FVC (%) in women. Blood pressure was found to be an independent factor of FEV(1)/FVC in men, whereas blood pressure, fasting plasma glucose and HDL-cholesterol independently determined FEV(1)/FVC in women. These findings suggest that sex-specific association between MetS and lung function measures should be considered in clinical practice.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Moo Young(김무영)
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
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