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Clinical predictors of drug response in patients with obsessive-compulsive disorder

 Chan-Hyung Kim  ;  Jae-Wook Jeong  ;  Min-Seong Koo  ;  Hong Shick Lee  ;  Ho Suk Suh  ;  Yoon Shick Shin  ;  Eun Ju Kim 
 Clinical Psychopharmacology and Neuroscience, Vol.9(1) : 23-28, 2011 
Journal Title
 Clinical Psychopharmacology and Neuroscience 
Issue Date
OBJECTIVE: The aim of this study was to evaluate which clinical variables might influence the antiobsessional responses to proserotonergic drugs in a sample of patients with obsessive-compulsive disorder (OCD). METHODS: Two hundred forty-nine patients with DSM-IV OCD under-gone mean 13-month treatments with selective serotonin reuptake inhibitors. According to the treatment response, defined as a reductions of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score ≥35%, patients were divided into two groups. RESULTS: One hundred fourteen patients responded to the treatment and the other one hundred thirty five patients did not. Responders had a significant long duration of medication in YUMC OCD clinic, short total duration of past treatment in other institutes, and higher frequency of drug naïve cases and lower baseline Y-BOCS scores. CONCLUSION: The pre-treatment factors including total duration of past treatment, drug naïve or not, baseline OCD symptoms and the factor of duration of the treatment may influence drug treatment response in OCD patients.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김찬형(Kim, Chan Hyung) ; 이홍식(Lee, Hong Shick)
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