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Quercetin inhibits IL-1β-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves' orbitopathy

Authors
 Jin Sook Yoon  ;  Hyun Jung Lee  ;  Eun Jig Lee  ;  Sang Yeul Lee  ;  Eun-Ju Chang  ;  Soo Hyun Choi 
Citation
 PLoS One, Vol.6(10) : e26261, 2011 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2011
Abstract
Management of Graves' orbitopathy (GO) is challenging, as no reliable, specific, and safe medical therapeutic agents have yet been developed. We investigated the effect of quercetin in primary cultured orbital fibroblasts from GO, targeting pathways of inflammation, aberrant accumulation of extracellular matrix macromolecules, and adipose tissue expansion. Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1β-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Increased hyaluronan production induced by IL-1β or tumor necrosis factor-α was suppressed by quercetin in a dose- and time-dependent manner. Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and C/EBPβ proteins. In conclusion, inhibition of inflammation, hyaluronan production, and adipogenesis by the natural plant product quercetin in vitro provides the basis for further study of its potential use in the treatment of GO
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94958
DOI
10.1371/journal.pone.0026261
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)
Yonsei Authors
윤진숙(Yoon, Jin Sook) ; 이상열(Lee, Sang Yeul) ; 이은직(Lee, Eun Jig) ; 이현정(Lee, Hyun Jung)
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