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간이식 후 초기 균 배양 양성결과가 단기 간이식 성적에 미치는 영향

Other Titles
 Impact of Early Positive Culture Results on the Short-term Outcomes of Liver Transplants 
Authors
 조 인 ; 주동진 ; 김순일 ; 최진섭 ; 최기홍 ; 허규하 ; 용동은 ; 김명수 
Citation
 Journal of the Korean Society for Transplantation(대한이식학회지), Vol.25(4) : 257~263, 2011 
Journal Title
 Journal of the Korean Society for Transplantation(대한이식학회지) 
ISSN
 1598-1711 
Issue Date
2011
Abstract
BACKGROUND: Infection is a major cause of morbidity and mortality following liver transplants. We evaluated the risk factors of mortality within 1 month of liver transplantation caused by post-transplant infections. METHODS: We retrospectively reviewed the medical records of 199 patients who underwent liver transplants from September 2005 to August 2010. We divided the enrolled patients into 3 groups. The first group, the Culture(-) group, was defined as those who had no significant culture results. The second group, the Culture(+)/survival group, was defined as those who tested positive for culture but survived longer than 1 month after transplantation. The third group, the Culture(+)/mortality group, was defined as those who died within 1 month of the transplant with positive culture test results. RESULTS: The culture(+)/mortality group consisted of more deceased donor liver transplants than other groups. Also, the Culture(+)/mortality group showed more evidence of pre-transplant infections, intensive care unit (ICU) admission, continuous post-transplant renal replacement therapy (CRRT), and a higher MELD score than other groups. The risk factors of early mortality combined with infection 1 month after liver transplantation are hospitalization in ICU before transplantation (HR=16.3, CI=2.6~102.3, P=0.003) and the positive results of culture within 7 days of the operation (HR=38.7, CI=4.1~368.8, P=0.001). CONCLUSIONS: Hospitalization in ICU before transplantation and an early positive culture result can be an early clinical indicator of a good prognosis after liver transplantation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94931
DOI
10.4285/jkstn.2011.25.4.257
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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