Cited 8 times in
Decrease of GABAergic markers and arc protein expression in the frontal cortex by intraventricular 192 IgG-saporin.
DC Field | Value | Language |
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dc.contributor.author | 이동규 | - |
dc.contributor.author | 장원석 | - |
dc.contributor.author | 장진우 | - |
dc.contributor.author | 정다운 | - |
dc.contributor.author | 황용섭 | - |
dc.date.accessioned | 2014-12-20T17:33:34Z | - |
dc.date.available | 2014-12-20T17:33:34Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1420-8008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94827 | - |
dc.description.abstract | BACKGROUND/AIMS: Previous studies used 192 IgG-saporin to study cholinergic function because of its facility for selective lesioning; however, results varied due to differences in the methods of administration and behavioral tests used. We examined an animal model of dementia using 192 IgG-saporin to confirm its features before applying this model to research of therapeutic drugs or electrical stimulation techniques. METHODS: Features were verified by the Morris water maze test, immunochemistry, and Western blotting. Animals were examined after intraventricular injection of 192 IgG-saporin (0.63 μg/μl; 6, 8, and 10 μl) or phosphate-buffered saline. RESULTS: In the acquisition phase of the Morris water maze test, the latencies of the injection groups were significantly delayed, but recovered within 1 week. In the probe test, 2 of 4 indices (time in the platform zone and the number of crossings) were significantly different in the 8-μl injection group. Immunohistochemistry revealed the extent of cholinergic destruction. Activity-regulated cytoskeleton-associated protein and glutamate decarboxylase expression significantly decreased in the frontal cortex (8- and 10-μl groups), but not in the hippocampus. CONCLUSION: Spatial memory impairment was associated with cholinergic basal forebrain injury as well as frontocortical GABAergic hypofunction and synaptic plasticity deceleration. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 70~78 | - |
dc.relation.isPartOf | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetylcholinesterase/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/administration & dosage | - |
dc.subject.MESH | Antibodies, Monoclonal/pharmacology* | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Choline O-Acetyltransferase/metabolism | - |
dc.subject.MESH | Cholinergic Agents/administration & dosage | - |
dc.subject.MESH | Cholinergic Agents/pharmacology* | - |
dc.subject.MESH | Cytoskeletal Proteins/biosynthesis* | - |
dc.subject.MESH | Dementia/chemically induced | - |
dc.subject.MESH | Dementia/psychology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Frontal Lobe/drug effects | - |
dc.subject.MESH | Frontal Lobe/metabolism* | - |
dc.subject.MESH | Glutamate Decarboxylase/metabolism | - |
dc.subject.MESH | Hippocampus/drug effects | - |
dc.subject.MESH | Hippocampus/metabolism | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Injections, Intraventricular | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maze Learning/drug effects | - |
dc.subject.MESH | Nerve Tissue Proteins/biosynthesis* | - |
dc.subject.MESH | Neuronal Plasticity/drug effects | - |
dc.subject.MESH | Parvalbumins/metabolism | - |
dc.subject.MESH | Prosencephalon/drug effects | - |
dc.subject.MESH | Prosencephalon/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Ribosome Inactivating Proteins, Type 1/administration & dosage | - |
dc.subject.MESH | Ribosome Inactivating Proteins, Type 1/pharmacology* | - |
dc.subject.MESH | Synapses/drug effects | - |
dc.subject.MESH | gamma-Aminobutyric Acid/physiology* | - |
dc.title | Decrease of GABAergic markers and arc protein expression in the frontal cortex by intraventricular 192 IgG-saporin. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Jeong D.U | - |
dc.contributor.googleauthor | Chang W.S. | - |
dc.contributor.googleauthor | Hwang Y.S. | - |
dc.contributor.googleauthor | Lee D. | - |
dc.contributor.googleauthor | Chang J.W | - |
dc.identifier.doi | 10.1159/000330741 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02721 | - |
dc.contributor.localId | A03484 | - |
dc.contributor.localId | A03586 | - |
dc.contributor.localId | A04475 | - |
dc.contributor.localId | A03454 | - |
dc.relation.journalcode | J00696 | - |
dc.identifier.eissn | 1421-9824 | - |
dc.identifier.pmid | 21876356 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/330741 | - |
dc.subject.keyword | Cholinergic systems | - |
dc.subject.keyword | Glutamic acid decarboxylase | - |
dc.subject.keyword | Immediate-early gene | - |
dc.subject.keyword | Medial forebrain bundle | - |
dc.subject.keyword | Memory | - |
dc.subject.keyword | Saporin | - |
dc.contributor.alternativeName | Lee, Dongkyu | - |
dc.contributor.alternativeName | Chang, Won Seok | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.alternativeName | Jeong, Da Un | - |
dc.contributor.alternativeName | Hwang, Yong Sup | - |
dc.contributor.affiliatedAuthor | Lee, Dongkyu | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Jeong, Da Un | - |
dc.contributor.affiliatedAuthor | Hwang, Yong Sup | - |
dc.contributor.affiliatedAuthor | Chang, Won Seok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 78 | - |
dc.identifier.bibliographicCitation | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, Vol.32(1) : 70-78, 2011 | - |
dc.identifier.rimsid | 27780 | - |
dc.type.rims | ART | - |
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