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A quantitative comparison of basal ganglia neuronal activities of normal and Parkinson's disease model rats

Authors
 Sang Baek Ryu  ;  Eun Kyung Bae  ;  Yong Sup Hwang  ;  Hyun Joo Lee  ;  ChangKyun Im  ;  Jin Woo Chang  ;  Hyung-Cheul Shin  ;  Kyung Hwan Kim 
Citation
 NEUROSCIENCE LETTERS, Vol.505(2) : 113-118, 2011 
Journal Title
NEUROSCIENCE LETTERS
ISSN
 0304-3940 
Issue Date
2011
MeSH
Action Potentials/physiology* ; Animals ; Globus Pallidus/pathology ; Globus Pallidus/physiopathology ; Male ; Neurons/pathology ; Neurons/physiology* ; Oxidopamine/toxicity ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/pathology* ; Parkinsonian Disorders/physiopathology* ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra/pathology ; Substantia Nigra/physiopathology ; Subthalamic Nucleus/pathology ; Subthalamic Nucleus/physiopathology
Keywords
Parkinson's disease ; Subthalamic nucleus ; Substantia nigra pars reticulate ; Globus pallidus ; Spike train analysis ; Neuronal firing pattern
Abstract
The purpose of this study was to identify consistent characteristic changes of neuronal activity in basal ganglia (BG) nuclei associated with Parkinson's disease (PD) so that a reliable index of PD can be derived. A simple algorithm for automatic identification of firing patterns was devised as an essential tool to achieve this goal. A detailed quantitative analysis of firing patterns as well as firing rate was performed in three BG nuclei: the subthalamic nucleus (STN), the substantia nigra pars reticulate (SNpr), and the globus pallidus (GP). The results showed that the firing rate of STN neurons was not significantly altered in PD model rats. We also did not find a significant alteration in firing rates in the SNpr and GP between normal and PD model rats. In contrast, consistent changes of firing patterns were observed in all three BG nuclei in that the percentage of neurons with a regular firing pattern decreased whereas those with irregular, mixed, or burst patterns increased. This enables a simple algorithm based on burst detection and the shape of the interspike interval histogram to identify whether the neuronal activity is from normal or PD model rats.
Full Text
http://linkinghub.elsevier.com/retrieve/pii/S0304-3940(11)01386-3
DOI
10.1016/j.neulet.2011.10.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Hwang, Yong Sup(황용섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94826
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