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Cognitive and behavioral effects of lamotrigine and carbamazepine monotherapy in patients with newly diagnosed or untreated partial epilepsy

Authors
 Sang-Ahm Lee  ;  Hyang-Woon Lee  ;  Kyoung Heo  ;  Dong-Jin Shin  ;  Hong-Ki Song  ;  Ok-Joon Kim  ;  Sun-Mi Lee  ;  Seon-Ok Kim  ;  Byung-In Lee 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.20(1) : 49-54, 2011 
Journal Title
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
ISSN
 1059-1311 
Issue Date
2011
MeSH
Adolescent ; Adult ; Behavior/drug effects* ; Behavior/physiology ; Carbamazepine/administration & dosage* ; Cognition/drug effects* ; Cognition/physiology ; Epilepsies, Partial/diagnosis* ; Epilepsies, Partial/drug therapy* ; Epilepsies, Partial/psychology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Prospective Studies ; Quality of Life/psychology ; Treatment Outcome ; Triazines/administration & dosage* ; Young Adult
Keywords
Epilepsy ; Cognition ; Behavior ; Carbamazepine ; Lamotrigine
Abstract
PURPOSE: In this prospective study, we compared the long-term cognitive and behavioral effects of lamotrigine (LTG) and carbamazepine (CBZ) in patients with newly diagnosed or untreated partial epilepsy.

METHODS: This was a multicenter, open-label, randomized study that compared monotherapy with LTG and CBZ in newly diagnosed or untreated patients with partial epilepsy. We employed an 8-week titration period and a 40-week maintenance period. Neuropsychological tests, Symptom Check List-90, and QOLIE-31 were assessed at baseline, 16 weeks, and 48 weeks after drug treatment. A group-by-time interaction was the primary outcome measure and was analyzed by use of the linear mixed model.

RESULTS: A total of 110 patients were eligible and 73 completed the 48-week study (LTG, n=39; CBZ, n=34). Among the cognitive tests, significant group-by-time interaction was identified only in phonemic fluency of Controlled Oral Word Association Task (p=0.0032) and Stroop Color-Word Interference (p=0.0283), with a significant better performance for LTG group. All other neuropsychological tests included did not show significant group-by-time interactions. Among the subscales of Symptom Check List-90, significant group-by-time interactions were identified in Obsessive-Compulsive (p=0.0005), Paranoid Ideation (p=0.0454), Global Severity Index (p=0.0194), and Positive Symptom Total (p=0.0197), with a significant improvement for CBZ group. QOLIE-31 did not show significant group-by-time interactions.

CONCLUSION: Our data suggest that epilepsy patients on LTG have better performance on phonemic fluency and the task of Stroop Color-Word Interference than do patients on CBZ, whereas patients on CBZ had more favorable behavioral effects on two subscales and two global scores of Symptom Check List-90 than did patients on LTG.
Full Text
http://www.sciencedirect.com/science/article/pii/S1059131110002372
DOI
10.1016/j.seizure.2010.10.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung In(이병인)
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94717
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