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Low plasma levels of the soluble receptor for advanced glycation end products in HIV-infected patients with subclinical carotid atherosclerosis receiving combined antiretroviral therapy

Authors
 Su Jin Jeong  ;  Chang Oh Kim  ;  Young Goo Song  ;  Ji-hyeon Baek  ;  Sun Bean Kim  ;  Sung Joon Jin  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Hyun Chul Lee  ;  June Myung Kim 
Citation
 ATHEROSCLEROSIS, Vol.219(12) : 778-783, 2011 
Journal Title
ATHEROSCLEROSIS
ISSN
 0021-9150 
Issue Date
2011
MeSH
Adult ; Analysis of Variance ; Anti-Retroviral Agents/adverse effects* ; Asymptomatic Diseases ; Biomarkers/blood ; Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/etiology* ; Chi-Square Distribution ; Cross-Sectional Studies ; Down-Regulation ; Drug Therapy, Combination ; HIV Infections/blood ; HIV Infections/drug therapy* ; Humans ; Linear Models ; Male ; Middle Aged ; Prospective Studies ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic/blood* ; Republic of Korea ; Risk Assessment ; Risk Factors ; Time Factors ; Tunica Intima/diagnostic imaging ; Tunica Media/diagnostic imaging ; Ultrasonography
Keywords
Atherosclerosis ; Carotid artery intima–media thickness ; Combined antiretroviral therapy ; HIV infection ; Soluble receptor for advanced glycation end products
Abstract
OBJECTIVE: Combined antiretroviral therapy (cART) has significantly improved the survival rate and quality of life for HIV-infected subjects, but it contributes to the development of metabolic complications including coronary artery disease (CAD). Recent studies have reported that high plasma levels of the soluble receptor for advanced glycation end products (sRAGE) were associated with a lower incidence of CAD in non-HIV infected patients. However, there has been no report of an association of sRAGE and subclinical carotid atherosclerosis in HIV-infected patients receiving cART.

METHODS: We examined the association of circulating sRAGE in HIV-infected patients with carotid intima-media thickness (IMT) and other metabolic variables. We prospectively enrolled 76 HIV-infected patients receiving cART for ≥ 6 months.

RESULTS: sRAGE had a significantly negative correlation with body mass index (r = -0.324, p = 0.005), waist-to-hip ratio (r = -0.335, p = 0.003), systolic blood pressure (BP) (r=-0.359, p=0.002), diastolic BP (r = -0.343, p = 0.004), total cholesterol (r = -0.240, p = 0.037), low-density lipoprotein-cholesterol (r=-0.284, p=0.024), log(homeostasis model assessment of insulin resistance [HOMA-IR]) (r = -0.380, p = 0.002) and carotid IMT including max-IMT and mean-IMT (r = -0.358, p = 0.001 and r = -0.329, p = 0.004, respectively). By the use of multiple stepwise regression analyses, systolic BP (p=0.001) and log[HOMA-IR] (p = 0.001) remained significant independently.

CONCLUSIONS: These results suggest that sRAGE may have a protective effect against subclinical atherosclerosis by preventing inflammatory responses mediated by the activation of cell surface RAGE in HIV-infected patients receiving cART.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915011007520
DOI
10.1016/j.atherosclerosis.2011.08.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Sun Bean(김선빈)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Hyun Chul(이현철)
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jin, Sung Joon(진성준)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94696
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