Cited 12 times in
Intraoperative multiple-staged resection and tumor tissue identification using frozen sections provide the best result for the accurate localization and complete resection of tumors in Cushing's disease.
DC Field | Value | Language |
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dc.contributor.author | 이은직 | - |
dc.contributor.author | 임정수 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 김선호 | - |
dc.date.accessioned | 2014-12-20T17:28:32Z | - |
dc.date.available | 2014-12-20T17:28:32Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94671 | - |
dc.description.abstract | The treatment of choice in Cushing's disease (CD) is surgical removal; however, most tumors are too small to be detected. The objective was to establish a method to achieve the complete removal of tumors on the basis of the results of high-resolution magnetic resonance imaging (MRI), inferior petrosal sinus sampling (IPSS), and a surgical resection technique using frozen biopsy. Eighteen patients who underwent transsphenoidal surgery from 2004 to 2010 were included. High-resolution MRI and IPSS, multiple-staged resection, and tumor tissue identification in frozen sections (surgical and histological identification, SHI) were performed. All patients achieved surgical remission, as confirmed by 24 h urinary free cortisol excretion tests. Visible microlesions were identified on the initial MRI in 11 patients (61%). The SHI findings agreed with the MRI findings in 10 of the 11 patients (90.9%) and with IPSS lateralization in 6 of the 11 patients (54.5%). In the 7 patients whose lesions were not visible on the initial MRI, only 1 (14.3%) showed an agreement between IPSS and SHI. In 3 of the 7 patients, the microlesions were identified by additional MRI. The rate of concordance with SHI was 77.8% for the overall MRI and 38.9% for IPSS. High-resolution MRI is better than IPSS for localizing corticotroph adenomas. In patients with lesions not visible on the initial MRI, additional MRI should be performed using a different protocol. Although high-resolution MRI is better for localizing tumors, SHI remains an important approach for removing the tumors completely. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 452~461 | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cushing Syndrome/blood | - |
dc.subject.MESH | Cushing Syndrome/pathology | - |
dc.subject.MESH | Cushing Syndrome/surgery* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Frozen Sections | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsurgery/methods | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monitoring, Intraoperative/methods | - |
dc.subject.MESH | Neurosurgical Procedures/methods* | - |
dc.subject.MESH | Petrosal Sinus Sampling/methods | - |
dc.subject.MESH | Pituitary Neoplasms/blood | - |
dc.subject.MESH | Pituitary Neoplasms/pathology | - |
dc.subject.MESH | Pituitary Neoplasms/surgery* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Intraoperative multiple-staged resection and tumor tissue identification using frozen sections provide the best result for the accurate localization and complete resection of tumors in Cushing's disease. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Jung Soo Lim | - |
dc.contributor.googleauthor | Seung Ku Lee | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Sun Ho Kim | - |
dc.identifier.doi | 10.1007/s12020-011-9499-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03401 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A00560 | - |
dc.relation.journalcode | J00768 | - |
dc.identifier.eissn | 1559-0100 | - |
dc.identifier.pmid | 21688179 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12020-011-9499-5 | - |
dc.subject.keyword | Cushing’s disease | - |
dc.subject.keyword | Localization | - |
dc.subject.keyword | High-resolution MRI | - |
dc.subject.keyword | Inferior petrosal sinus sampling | - |
dc.subject.keyword | Surgical and histological identification | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Lim, Jung Soo | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Kim, Sun Ho | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lim, Jung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Kim, Sun Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 452 | - |
dc.citation.endPage | 461 | - |
dc.identifier.bibliographicCitation | ENDOCRINE, Vol.40(3) : 452-461, 2011 | - |
dc.identifier.rimsid | 27668 | - |
dc.type.rims | ART | - |
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