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The role of preoperative [18F]fluorodeoxyglucose positron emission tomography in predicting early recurrence after curative resection of hepatocellular carcinomas.

Authors
 Sung Gwe Ahn  ;  Sung Hoon Kim  ;  Tae Joo Jeon  ;  Ho Jin Cho  ;  Sae Byeol Choi  ;  Mi Jin Yun  ;  Jong Doo Lee  ;  Kyung Sik Kim 
Citation
 JOURNAL OF GASTROINTESTINAL SURGERY, Vol.15(11) : 2044-2052, 2011 
Journal Title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN
 1091-255X 
Issue Date
2011
MeSH
Adult ; Aged ; Carcinoma, Hepatocellular/diagnostic imaging* ; Carcinoma, Hepatocellular/pathology* ; Carcinoma, Hepatocellular/surgery ; Disease-Free Survival ; Fluorodeoxyglucose F18 ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/diagnostic imaging* ; Liver Neoplasms/pathology* ; Liver Neoplasms/surgery ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis* ; Neoplasm Staging ; Positron-Emission Tomography* ; Predictive Value of Tests ; Proportional Hazards Models ; Radiopharmaceuticals ; Retrospective Studies ; Time Factors
Keywords
Hepatocellular carcinoma ; Early recurrence ; 18F-FDG PET
Abstract
PURPOSE: (18)F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan reflects tumor differentiation and predicts clinical outcome in patients with hepatocellular carcinoma (HCC). We investigated the correlation of PET scans with tumor differentiation and early tumor recurrence (time-to-recurrence <1 year).

METHODS: We reviewed the medical records of 93 patients with HCC who underwent curative resection at our hospital from August 2004 through December 2008. PET scans were performed preoperatively, and the maximum standardized uptake value of the tumor (SUV(tumor)) and the tumor-to-non-tumor SUV ratio (TNR) were calculated from FDG uptake.

RESULTS: Twenty-six (27.9%) had recurrences and 12 of them (46.2%) had early recurrences. SUV(tumor) and TNR correlated strongly with tumor differentiation (p < 0.001). Early recurrence-free and the overall survival rates in the low TNR group (TNR <2.0) were higher than in the high TNR group (TNR ≥2.0) (p = 0.015, p = 0.013). According to univariate analysis, predictors of early tumor recurrence were large tumor size (≥5 cm), high TNR (≥2), high SUV(tumor) (≥4), and high Edmoson-Steiner grade. However, on multivariate analysis, none of the examined factors were statistically significant independent predictor.

CONCLUSION: PET scans reflect tumor differentiation in HCCs. Because high TNR (TNR ≥2) and SUV(tumor) (SUV ≥4) were these cutoff point significant predictors in univariate analysis, future studies with more statistical power are needed to assess the significance.
Full Text
http://link.springer.com/article/10.1007%2Fs11605-011-1660-1
DOI
10.1007/s11605-011-1660-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Sung Hoon(김성훈)
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Yun, Mijin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jong Doo(이종두)
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
Cho, Hojin(조호진) ORCID logo https://orcid.org/0000-0002-8686-172X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94666
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