259 601

Cited 10 times in

Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage

Authors
 Mi-Jeong Kim  ;  Yoo-Hyun Lee  ;  Jieun Kwak  ;  Younghwa Na  ;  Ho-Geun Yoon 
Citation
 BMB REPORTS, Vol.44(11) : 730-734, 2011 
Journal Title
BMB REPORTS
ISSN
 1976-6696 
Issue Date
2011
MeSH
Amyloid beta-Peptides/administration & dosage ; Amyloid beta-Peptides/toxicity* ; Animals ; Body Weight/drug effects ; Cell Death/drug effects ; Cell Survival/drug effects ; Chalcone/administration & dosage ; Chalcone/analogs & derivatives* ; Chalcone/chemistry ; Chalcone/pharmacology* ; Free Radical Scavengers/pharmacology ; Male ; Memory/drug effects ; Mice ; Mice, Inbred ICR ; Neurons/drug effects* ; Neurons/pathology* ; Neuroprotective Agents/pharmacology* ; Oxidative Stress/drug effects* ; PC12 Cells ; Peptide Fragments/administration & dosage ; Peptide Fragments/toxicity* ; Rats
Keywords
Alzheimer's disease ; Chalcone derivative ; Cognitive function ; Neuroprotective effect ; β-amyloid
Abstract
Amyloid Β-peptide (AΒ-peptide)-induced oxidative stress is thought to be a critical component of the pathophysiology of Alzheimer's disease (AD). New chalcone derivatives, the Chana series, were recently synthesized from the retrochalcones of licorice. In this study, we investigated the protective effects of the Chana series against neurodegenerative changes in vitro and in vivo. Among the Chana series, Chana 30 showed the highest free radical scavenging activity (90.7%) in the 1,1-diphenyl-2- picrylhydrazyl assay. Chana 30 also protected against AΒ-induced neural cell injury in vitro. Furthermore, Chana 30 reduced the learning and memory deficits of AΒ(1-42)-peptide injected mice. Taken together, these results suggest that Chana 30 may be a promising candidate as a potent therapeutic agent against neurodegenerative diseases.
Files in This Item:
T201104160.pdf Download
DOI
10.5483/BMBRep.2011.44.11.730
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Jeong(김미정) ORCID logo https://orcid.org/0000-0002-0758-7145
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94646
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links