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Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage

Authors
 Mi-Jeong Kim ; Yoo-Hyun Lee ; Ho-Geun Yoon ; Younghwa Na ; Jieun Kwak 
Citation
 BMB Reports, Vol.44(11) : 730~734, 2011 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2011
Abstract
Amyloid Β-peptide (AΒ-peptide)-induced oxidative stress is thought to be a critical component of the pathophysiology of Alzheimer's disease (AD). New chalcone derivatives, the Chana series, were recently synthesized from the retrochalcones of licorice. In this study, we investigated the protective effects of the Chana series against neurodegenerative changes in vitro and in vivo. Among the Chana series, Chana 30 showed the highest free radical scavenging activity (90.7%) in the 1,1-diphenyl-2- picrylhydrazyl assay. Chana 30 also protected against AΒ-induced neural cell injury in vitro. Furthermore, Chana 30 reduced the learning and memory deficits of AΒ(1-42)-peptide injected mice. Taken together, these results suggest that Chana 30 may be a promising candidate as a potent therapeutic agent against neurodegenerative diseases.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94646
DOI
10.5483/BMBRep.2011.44.11.730
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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