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Mitochondrial DNA copy number in peripheral blood in polycystic ovary syndrome

Authors
 Sang-Hee Lee ; Da-Jung Chung ; Ji-Won Lee ; Duk-Chul Lee ; Jee-Aee Im ; Hyeon Jeong Jeong ; Myung-Hee Kim ; Tae-June Kim ; Hee-Sun Lee 
Citation
 Metabolism-Clinical and Experimental, Vol.60(12) : 1677~1682, 2011 
Journal Title
 Metabolism-Clinical and Experimental 
ISSN
 0026-0495 
Issue Date
2011
Abstract
Polycystic ovary syndrome (PCOS) is associated with insulin resistance and various metabolic diseases; and recently, elevated oxidative stress has been detected in PCOS. Mitochondria are highly susceptible to oxidative damage; and disordered mitochondrial function at the cellular level can impact whole-body metabolic homeostasis, leading to the hypothesis that abnormalities in markers of mitochondrial metabolism are related to PCOS. We compared mitochondrial DNA (mtDNA) copy number in women with and without PCOS and investigated the independent relationship between mtDNA copy number and PCOS after adjustment for metabolic parameters. Fifty women with PCOS and 60 age- and body mass index-matched healthy women were studied. Mitochondrial DNA copy numbers as well as metabolic parameters and indices of insulin resistance were assessed. Mitochondrial DNA copy numbers were significantly lower in women with PCOS (P < .01). In the PCOS group, mtDNA copy number was negatively correlated with indices of insulin resistance, waist circumference, and triglyceride levels and positively correlated with sex hormone-binding globulin levels. In multiple logistic regression, the corresponding odds ratios (95% confidence interval) for PCOS by log-transformed mtDNA copy number and homeostasis model assessment of insulin resistance were 0.15 (0.04-0.56) and 4.26 (1.43-12.68), respectively, after adjustment for age, body mass index, and other metabolic factors. We report decreased mtDNA copy numbers in PCOS patients in relation to controls independently of insulin resistance or other metabolic factors. The pathophysiological and clinical significance of this finding requires further investigation
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94590
DOI
10.1016/j.metabol.2011.04.010
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0026049511001132
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