2 67

Cited 58 times in

Effects of leptin and adiponectin on pancreatic β-cell function

Authors
 Yong-ho Lee ; Faidon Magkos ; Eun Seok Kang ; Christos S. Mantzoros 
Citation
 Metabolism-Clinical and Experimental, Vol.60(12) : 1664~1672, 2011 
Journal Title
 Metabolism-Clinical and Experimental 
ISSN
 0026-0495 
Issue Date
2011
Abstract
Leptin and adiponectin are hormones secreted from adipocytes that have important roles in metabolism and energy homeostasis. This review evaluates the effects of leptin and adiponectin on β-cell function by analyzing and compiling results from human clinical trials and epidemiologic studies as well as in vitro and in vivo experiments. Leptin has been shown to inhibit ectopic fat accumulation and thereby prevent β-cell dysfunction and protect the β-cell from cytokine- and fatty acid-induced apoptosis. However, leptin suppresses insulin gene expression and secretion as well as glucose transport into the β-cell. Adiponectin stimulates insulin secretion by enhancing exocytosis of insulin granules and upregulating the expression of the insulin gene; however, this effect depends on the prevailing glucose concentration and status of insulin resistance. In addition, adiponectin has antiapoptotic properties in β-cells. Available evidence concerning the role of these adipokines on insulin secretion, insulin gene expression, and apoptosis is not always entirely consistent; and many fundamental questions remain to be answered by future studies
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94540
DOI
10.1016/j.metabol.2011.04.008
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0026049511001119
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse