Cited 106 times in
Effects of leptin and adiponectin on pancreatic β-cell function
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 이용호 | - |
dc.date.accessioned | 2014-12-20T17:24:19Z | - |
dc.date.available | 2014-12-20T17:24:19Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94540 | - |
dc.description.abstract | Leptin and adiponectin are hormones secreted from adipocytes that have important roles in metabolism and energy homeostasis. This review evaluates the effects of leptin and adiponectin on β-cell function by analyzing and compiling results from human clinical trials and epidemiologic studies as well as in vitro and in vivo experiments. Leptin has been shown to inhibit ectopic fat accumulation and thereby prevent β-cell dysfunction and protect the β-cell from cytokine- and fatty acid-induced apoptosis. However, leptin suppresses insulin gene expression and secretion as well as glucose transport into the β-cell. Adiponectin stimulates insulin secretion by enhancing exocytosis of insulin granules and upregulating the expression of the insulin gene; however, this effect depends on the prevailing glucose concentration and status of insulin resistance. In addition, adiponectin has antiapoptotic properties in β-cells. Available evidence concerning the role of these adipokines on insulin secretion, insulin gene expression, and apoptosis is not always entirely consistent; and many fundamental questions remain to be answered by future studies | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1664~1672 | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/metabolism | - |
dc.subject.MESH | Adiponectin/physiology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Apoptosis/genetics | - |
dc.subject.MESH | Clinical Trials as Topic | - |
dc.subject.MESH | Epidemiologic Studies | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin/metabolism* | - |
dc.subject.MESH | Insulin/secretion | - |
dc.subject.MESH | Insulin Resistance | - |
dc.subject.MESH | Insulin-Secreting Cells/drug effects | - |
dc.subject.MESH | Insulin-Secreting Cells/metabolism* | - |
dc.subject.MESH | Leptin/metabolism | - |
dc.subject.MESH | Leptin/physiology* | - |
dc.title | Effects of leptin and adiponectin on pancreatic β-cell function | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yong-ho Lee | - |
dc.contributor.googleauthor | Faidon Magkos | - |
dc.contributor.googleauthor | Christos S. Mantzoros | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.identifier.doi | 10.1016/j.metabol.2011.04.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02989 | - |
dc.relation.journalcode | J02223 | - |
dc.identifier.eissn | 1532-8600 | - |
dc.identifier.pmid | 21632069 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0026049511001119 | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 60 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1664 | - |
dc.citation.endPage | 1672 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.60(12) : 1664-1672, 2011 | - |
dc.identifier.rimsid | 27399 | - |
dc.type.rims | ART | - |
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