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Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells

Authors
 Seunghee Bae  ;  Eun-Mee Lee  ;  Hwa Jun Cha  ;  Karam Kim  ;  Yeongmin Yoon  ;  Hyunjin Lee  ;  Jongran Kim  ;  Yu-Jeong Kim  ;  Hong Ghi Lee  ;  Hoi-Kyung Jeung  ;  Yoo Hong Min  ;  Sungkwan An 
Citation
 MOLECULES AND CELLS, Vol.32(3) : 243-249, 2011 
Journal Title
MOLECULES AND CELLS
ISSN
 1016-8478 
Issue Date
2011
MeSH
Antineoplastic Agents, Phytogenic/pharmacology* ; Antineoplastic Agents, Phytogenic/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy* ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic*/drug effects ; Humans ; Lung/drug effects* ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/drug therapy* ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism* ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Stilbenes/pharmacology* ; Stilbenes/therapeutic use
Keywords
A549 ; human non-small cell lung cancer cells ; microRNA ; resveratrol
Abstract
Resveratrol is a plant phenolic phytoalexin that has been reported to have antitumor properties in several types of cancers. In particular, several studies have suggested that resveratrol exerts antiproliferative effects against A549 human non-small cell lung cancer cells; however, its mechanism of action remains incompletely understood. Deregulation of microRNAs (miRNAs), a class of small, noncoding, regulatory RNA molecules involved in gene expression, is strongly correlated with lung cancer. In this study, we demonstrated that resveratrol treatment altered miRNA expression in A549 cells. Using microarray analysis, we identified 71 miRNAs exhibiting greater than 2-fold expression changes in resveratrol-treated cells relative to their expression levels in untreated cells. Furthermore, we identified target genes related to apoptosis, cell cycle regulation, cell proliferation, and differentiation using a miRNA target-prediction program. In conclusion, our data demonstrate that resveratrol induces considerable changes in the miRNA expression profiles of A549 cells, suggesting a novel approach for studying the anticancer mechanisms of resveratrol.
Full Text
http://dx.doi.org/10.1007/s10059-011-1037-z
DOI
10.1007/s10059-011-1037-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Jeung, Hoi Kyung(정회경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94526
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