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Serum kisspeptin levels in Korean girls with central precocious puberty

Authors
 Young Jun Rhie  ;  Kee Hyoung Lee  ;  So Hee Eun  ;  Byung Min Choi  ;  Hyun Wook Chae  ;  Ah Reum Kwon  ;  Woo Jung Lee  ;  Jung Hyun Kim  ;  Ho-Seong Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(7) : 927-931, 2011 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2011
MeSH
Biomarkers/blood ; Child ; Female ; Follicle Stimulating Hormone/blood ; Humans ; Kisspeptins ; Luteinizing Hormone/blood ; Puberty, Precocious/blood ; Puberty, Precocious/diagnosis* ; Republic of Korea ; Tumor Suppressor Proteins/blood*
Keywords
CentralPrecociousPuberty ; G-protein Coupled Receptor-54 ; Gonadotropin-Releasing Hormone ; KISS1 Gene ; Kisspeptin
Abstract
Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.
Files in This Item:
T201103488.pdf Download
DOI
10.3346/jkms.2011.26.7.927
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ah Reum(권아름) ORCID logo https://orcid.org/0000-0002-9692-2135
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Rhie, Young Jun(이영준)
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94390
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