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Serum kisspeptin levels in Korean girls with central precocious puberty

 So Hee Eun  ;  Byung Min Choi  ;  Kee Hyoung Lee  ;  Young Jun Rhie  ;  Ho-Seong Kim  ;  Jung Hyun Kim  ;  Woo Jung Lee  ;  Ah Reum Kwon  ;  Hyun Wook Chae 
 Journal of Korean Medical Science, Vol.26(7) : 927-931, 2011 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
권아름(Kwon, Ah Reum) ; 김호성(Kim, Ho Seong) ; 이영준(Rhie, Young Jun) ; 이우정(Lee, Woo Jung) ; 채현욱(Chae, Hyun Wook)
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