Cited 42 times in
Serum kisspeptin levels in Korean girls with central precocious puberty
DC Field | Value | Language |
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dc.contributor.author | 권아름 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 이영준 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2014-12-20T17:19:37Z | - |
dc.date.available | 2014-12-20T17:19:37Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94390 | - |
dc.description.abstract | Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 927~931 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follicle Stimulating Hormone/blood | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kisspeptins | - |
dc.subject.MESH | Luteinizing Hormone/blood | - |
dc.subject.MESH | Puberty, Precocious/blood | - |
dc.subject.MESH | Puberty, Precocious/diagnosis* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Tumor Suppressor Proteins/blood* | - |
dc.title | Serum kisspeptin levels in Korean girls with central precocious puberty | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Young Jun Rhie | - |
dc.contributor.googleauthor | Kee Hyoung Lee | - |
dc.contributor.googleauthor | So Hee Eun | - |
dc.contributor.googleauthor | Byung Min Choi | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Ah Reum Kwon | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Jung Hyun Kim | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.identifier.doi | 10.3346/jkms.2011.26.7.927 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A02961 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 21738347 | - |
dc.subject.keyword | CentralPrecociousPuberty | - |
dc.subject.keyword | G-protein Coupled Receptor-54 | - |
dc.subject.keyword | Gonadotropin-Releasing Hormone | - |
dc.subject.keyword | KISS1 Gene | - |
dc.subject.keyword | Kisspeptin | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.alternativeName | Rhie, Young Jun | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Chae, Hyun Wook | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | Rhie, Young Jun | - |
dc.contributor.affiliatedAuthor | Chae, Hyun Wook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 927 | - |
dc.citation.endPage | 931 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(7) : 927-931, 2011 | - |
dc.identifier.rimsid | 27588 | - |
dc.type.rims | ART | - |
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