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Antioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system

DC Field Value Language
dc.contributor.author오영택-
dc.date.accessioned2014-12-20T17:17:56Z-
dc.date.available2014-12-20T17:17:56Z-
dc.date.issued2011-
dc.identifier.issn0927-7765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94335-
dc.description.abstractThe purpose of this study was to fabricate porous poly(lactide-co-glycolide) (PLGA) microparticles for efficient pulmonary deposition and increased therapeutic duration of the antioxidant anthocyanin (ATH). These microparticles were prepared by a water-in-oil-in-water (W(1)/O/W(2)) multi-emulsion method with vaporizing ammonium bicarbonate (AB) as a porogen and starch as a viscous additive. High porosity achieved by the decomposition reaction of AB to the base of ammonia, carbon dioxide, and water vapor at 50°C enabled efficient deposition of ATH throughout the entire lung in BALB/c mice. In addition, the porous microparticles incorporating starch showed sustained ATH release characteristics (up to 5 days) and protracted antioxidant activity (up to 5 days) for 2,2-diphenyl-1-pikryl-hydrazyl (DPPH) radicals, which was comparable to that of the porous microparticles without starch which completely released ATH in 2h. Furthermore, these porous microparticles incorporating starch led to longer ATH residence (up to 20 days) in in vivo lung epithelium. We believe that this system has great pharmaceutical potential as a long-acting antioxidant for continuously relieving oxidative stress in pulmonary diseases like chronic obstructive pulmonary disease (COPD).-
dc.description.statementOfResponsibilityopen-
dc.format.extent419~424-
dc.relation.isPartOfCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration,Inhalation*-
dc.subject.MESHAnimals-
dc.subject.MESHAnthocyanins/chemistry-
dc.subject.MESHAnthocyanins/therapeutic use-
dc.subject.MESHAntioxidants/chemistry*-
dc.subject.MESHAntioxidants/therapeutic use-
dc.subject.MESHCell Line-
dc.subject.MESHDrug Carriers/administration & dosage-
dc.subject.MESHDrug Carriers/chemistry*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLactic Acid/chemistry*-
dc.subject.MESHLung/metabolism*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHPolyglycolic Acid/chemistry*-
dc.subject.MESHPorosity-
dc.subject.MESHPulmonary Disease, Chronic Obstructive/drug therapy-
dc.titleAntioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorNa Young Yoo-
dc.contributor.googleauthorYu Seok Youn-
dc.contributor.googleauthorNam Muk Oh-
dc.contributor.googleauthorKyung Taek Oh-
dc.contributor.googleauthorDeok-Keun Lee-
dc.contributor.googleauthorKyung-Hoi Cha-
dc.contributor.googleauthorYoung Taik Oh-
dc.contributor.googleauthorEun Seong Lee-
dc.identifier.doi10.1016/j.colsurfb.2011.07.024-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02390-
dc.relation.journalcodeJ00627-
dc.identifier.eissn1873-4367-
dc.identifier.pmid21820282-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0927776511004279-
dc.subject.keywordPorous microparticle-
dc.subject.keywordAnthocyanin-
dc.subject.keywordPulmonary delivery-
dc.subject.keywordChronic obstructive pulmonary disease-
dc.contributor.alternativeNameOh, Young Taik-
dc.contributor.affiliatedAuthorOh, Young Taik-
dc.rights.accessRightsnot free-
dc.citation.volume88-
dc.citation.number1-
dc.citation.startPage419-
dc.citation.endPage424-
dc.identifier.bibliographicCitationCOLLOIDS AND SURFACES B-BIOINTERFACES, Vol.88(1) : 419-424, 2011-
dc.identifier.rimsid27552-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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