Cited 31 times in
Antioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system
DC Field | Value | Language |
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dc.contributor.author | 오영택 | - |
dc.date.accessioned | 2014-12-20T17:17:56Z | - |
dc.date.available | 2014-12-20T17:17:56Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94335 | - |
dc.description.abstract | The purpose of this study was to fabricate porous poly(lactide-co-glycolide) (PLGA) microparticles for efficient pulmonary deposition and increased therapeutic duration of the antioxidant anthocyanin (ATH). These microparticles were prepared by a water-in-oil-in-water (W(1)/O/W(2)) multi-emulsion method with vaporizing ammonium bicarbonate (AB) as a porogen and starch as a viscous additive. High porosity achieved by the decomposition reaction of AB to the base of ammonia, carbon dioxide, and water vapor at 50°C enabled efficient deposition of ATH throughout the entire lung in BALB/c mice. In addition, the porous microparticles incorporating starch showed sustained ATH release characteristics (up to 5 days) and protracted antioxidant activity (up to 5 days) for 2,2-diphenyl-1-pikryl-hydrazyl (DPPH) radicals, which was comparable to that of the porous microparticles without starch which completely released ATH in 2h. Furthermore, these porous microparticles incorporating starch led to longer ATH residence (up to 20 days) in in vivo lung epithelium. We believe that this system has great pharmaceutical potential as a long-acting antioxidant for continuously relieving oxidative stress in pulmonary diseases like chronic obstructive pulmonary disease (COPD). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 419~424 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration,Inhalation* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anthocyanins/chemistry | - |
dc.subject.MESH | Anthocyanins/therapeutic use | - |
dc.subject.MESH | Antioxidants/chemistry* | - |
dc.subject.MESH | Antioxidants/therapeutic use | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Drug Carriers/administration & dosage | - |
dc.subject.MESH | Drug Carriers/chemistry* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lactic Acid/chemistry* | - |
dc.subject.MESH | Lung/metabolism* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Polyglycolic Acid/chemistry* | - |
dc.subject.MESH | Porosity | - |
dc.subject.MESH | Pulmonary Disease, Chronic Obstructive/drug therapy | - |
dc.title | Antioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Na Young Yoo | - |
dc.contributor.googleauthor | Yu Seok Youn | - |
dc.contributor.googleauthor | Nam Muk Oh | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.contributor.googleauthor | Deok-Keun Lee | - |
dc.contributor.googleauthor | Kyung-Hoi Cha | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.identifier.doi | 10.1016/j.colsurfb.2011.07.024 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02390 | - |
dc.relation.journalcode | J00627 | - |
dc.identifier.eissn | 1873-4367 | - |
dc.identifier.pmid | 21820282 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0927776511004279 | - |
dc.subject.keyword | Porous microparticle | - |
dc.subject.keyword | Anthocyanin | - |
dc.subject.keyword | Pulmonary delivery | - |
dc.subject.keyword | Chronic obstructive pulmonary disease | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 88 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 419 | - |
dc.citation.endPage | 424 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.88(1) : 419-424, 2011 | - |
dc.identifier.rimsid | 27552 | - |
dc.type.rims | ART | - |
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