Cited 6 times in
Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.contributor.author | 조성애 | - |
dc.contributor.author | 홍성희 | - |
dc.date.accessioned | 2014-12-20T17:17:20Z | - |
dc.date.available | 2014-12-20T17:17:20Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1472-9792 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94315 | - |
dc.description.abstract | The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 300~307 | - |
dc.relation.isPartOf | TUBERCULOSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antitubercular Agents/adverse effects | - |
dc.subject.MESH | Antitubercular Agents/therapeutic use* | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cytokines/metabolism* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity, Cellular* | - |
dc.subject.MESH | Interferon-gamma/metabolism | - |
dc.subject.MESH | Interleukin-10/metabolism | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Practice Guidelines as Topic | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/drug therapy | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/immunology* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/surgery | - |
dc.subject.MESH | Young Adult | - |
dc.title | Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Seung-Kyu Park | - |
dc.contributor.googleauthor | Sunghee Hong | - |
dc.contributor.googleauthor | Seok-Yong Eum | - |
dc.contributor.googleauthor | In Hee Lee | - |
dc.contributor.googleauthor | Donk Ok Shin | - |
dc.contributor.googleauthor | Jang Eun Cho | - |
dc.contributor.googleauthor | Sungae Cho | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.identifier.doi | 10.1016/j.tube.2011.02.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A03835 | - |
dc.contributor.localId | A04407 | - |
dc.relation.journalcode | J02760 | - |
dc.identifier.eissn | 1873-281X | - |
dc.identifier.pmid | 21514229 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1472979211000266 | - |
dc.subject.keyword | Mycobacterium tuberculosis(Mtb) | - |
dc.subject.keyword | MDR-TB (Multidrug-resistant tuberculosis) | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | IL-10 | - |
dc.subject.keyword | Lung resection surgery | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Cho, Sung Ae | - |
dc.contributor.alternativeName | Hong, Sung Hee | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sung Ae | - |
dc.contributor.affiliatedAuthor | Hong, Sung Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 91 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 300 | - |
dc.citation.endPage | 307 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS, Vol.91(4) : 300-307, 2011 | - |
dc.identifier.rimsid | 27539 | - |
dc.type.rims | ART | - |
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