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Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey

 Terumi Kamisawa  ;  Suresh T. Chari  ;  Samuel A. Giday  ;  Myung-Hwan Kim  ;  Jae Bock Chung  ;  Kyu Taek Lee  ;  Jens Werner  ;  Frank Bergmann  ;  Markus M. Lerch  ;  Julia Mayerle  ;  Tilman Pickartz  ;  Matthias Lohr  ;  Alexander Schneider  ;  Luca Frulloni  ;  George J. M. Webster  ;  D. Nageshwar Reddy  ;  Wei-Chih Liao  ;  Hsiu-Po Wang  ;  Kazuichi Okazaki  ;  Tooru Shimosegawa  ;  Guenter Kloeppel  ;  Vay Liang W. Go 
 Pancreas, Vol.40(6) : 809-814, 2011 
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OBJECTIVE: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients. RESULTS: Patients with LPSP were approximately 16 years older than IDCP patients. Obstructive jaundice was a more frequent presentation in LPSP versus IDCP (75% vs 47%, P < 0.001), whereas abdominal pain (41% vs 68%, P < 0.001) and acute pancreatitis (5% vs 34%, P < 0.001) were more frequent in IDCP patients. Patients with LPSP were more likely to have diffuse swelling of the pancreas (40% vs 25%, P = 0.037) and elevated serum IgG4 levels (63% vs 23%, P < 0.001) but less likely to be associated with ulcerative colitis (1% vs 16%, P < 0.001). Clinical profiles of non-histologically confirmed AIP from Asia, the United States, and United Kingdom corresponded with that of LPSP, whereas those from Italy and Germany suggested a mixture of LPSP and IDCP. CONCLUSIONS: Autoimmune pancreatitis is seen all around the world, with regional differences in the pathologic and clinical features. Lymphoplasmacytic sclerosing pancreatitis and IDCP have distinct clinical profiles.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
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정재복(Chung, Jae Bock)
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