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Clinical implication of FDG-PET in advanced gastric cancer with signet ring cell histology.

Authors
 Kyung Ho Pak  ;  Mijin Yun  ;  Jae-Ho Cheong  ;  Woo Jin Hyung  ;  Seung Ho Choi  ;  Sung Hoon Noh 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.104(6) : 566-570, 2011 
Journal Title
JOURNAL OF SURGICAL ONCOLOGY
ISSN
 0022-4790 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma,SignetRingCell/diagnostic imaging* ; Carcinoma,SignetRingCell/pathology ; Carcinoma,SignetRingCell/surgery ; Female ; Fluorodeoxyglucose F18* ; Follow-Up Studies ; Gastrectomy ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography* ; Radiopharmaceuticals* ; Stomach Neoplasms/diagnostic imaging* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Rate ; Treatment Outcome
Keywords
standard uptake values ; signet ring cell carcinoma ; FDG–PET
Abstract
BACKGROUND AND OBJECTIVES: The purpose of this study was to investigate the role of the standardized uptake values (SUV), a semi-quantitative assessment of tumor FDG uptake, as a prognosticator for advanced signet ring cell carcinoma (SRC).

METHODS: We reviewed the files of 41 patients who underwent curative gastrectomy for advanced SRC and who had an FDG-PET at initial presentation between September 2003 and December 2007.

RESULTS: The median follow-up period was 30.9 months (range: 4.0-70.3). We found a correlation between the SUVmax and TNM stage. When the patients were divided into two groups (low vs. high SUVmax) based on a median SUVmax of 3.80, the high-SUVmax group showed more aggressive tumor behavior than did the low SUVmax group. In addition, the high SUVmax group showed more postoperative recurrence (P = 0.028), shorter relapse-free survival (P = 0.004), and lower 30-month cancer-specific survival rates (40.0% vs. 69.3%, P = 0.008). However, in multivariate analysis, SUVmax failed to be an independent predictor of overall survival.

CONCLUSIONS: Although SUVmax of initial PET scan was not an independent predictor of patient outcomes after curative surgery, higher SUVmax is associated with more advanced stage and indicates more aggressive tumor biology in advanced SRC.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.21997/abstract
DOI
10.1002/jso.21997
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Pak, Kyung Ho(박경호)
Yun, Mijin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94304
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