280 734

Cited 21 times in

Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro

Authors
 Eun Jung Bak  ;  Hong Gyu Park  ;  ChoongHwan Lee  ;  Tong-Il Lee  ;  Gye-Hyeong Woo  ;  Younghwa Na  ;  Yun-Jung Yoo  ;  Jeong-Heon Cha 
Citation
 BMB REPORTS, Vol.44(6) : 410-414, 2011 
Journal Title
BMB REPORTS
ISSN
 1976-6696 
Issue Date
2011
MeSH
Adipocytes/cytology ; Adipocytes/drug effects* ; Adipocytes/physiology* ; Animals ; Cell Differentiation/drug effects* ; Cell Line ; Chalcone/analogs & derivatives* ; Chalcone/metabolism ; Chalcone/pharmacology* ; Chalcone/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl Peptidase 4/metabolism* ; Dipeptidyl-Peptidase IV Inhibitors/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology* ; Enzyme Inhibitors/therapeutic use ; Glycoside Hydrolase Inhibitors* ; Humans ; Mice ; Multipotent Stem Cells/cytology ; Multipotent Stem Cells/physiology
Keywords
Adipocyte differentiation ; α-Glucosidase ; Chalcone derivates ; DPP-4
Abstract
Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.
Files in This Item:
T201103353.pdf Download
DOI
10.5483/BMBRep.2011.44.6.410
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Bak, Eun-Jung(박은정) ORCID logo https://orcid.org/0000-0002-7976-8594
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Cha, Jeong Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94222
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links