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Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice

Authors
 Jin-Nyoung Ho  ;  Eun-Ryung Kang  ;  Ho-Geun Yoon  ;  Hyelin Jeon  ;  Woojin Jun  ;  Ronal R. Watson  ;  Jeongmin Lee 
Citation
 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.75(7) : 1234-1239, 2011 
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN
 0916-8451 
Issue Date
2011
MeSH
Animals ; Cytokines/drug effects* ; Cytokines/immunology ; Cytokines/metabolism ; Disease Progression ; Female ; Isothiocyanates/pharmacology* ; Lipid Peroxidation/drug effects* ; Longevity/drug effects* ; Longevity/immunology ; Mice ; Mice, InbredC57BL ; Murine Acquired Immunodeficiency Syndrome/drug therapy* ; Murine Acquired Immunodeficiency Syndrome/immunology* ; Murine Acquired Immunodeficiency Syndrome/metabolism ; Oxidative Stress/drug effects* ; Th1 Cells/drug effects ; Th1 Cells/metabolism ; Th2 Cells/drug effects ; Th2 Cells/metabolism ; Thiocyanates/pharmacology ; Vitamin E/metabolism
Keywords
isothiocyanates ; murine AIDS ; immune dysfunction ; oxidative stress ; Th1 and Th2 cytokines
Abstract
The purpose of this study was to determine the effect of isothiocyanates (ITCs) in delaying the progression of the murine immunodeficiency virus to murine AIDS, resulting in increased life span. Furthermore, we investigated the role of ITCs in modulating immune dysfunction caused by LP-BM5 retrovirus infection. Among the tested ITCs, oral administration of sulforaphane (SUL), benzyl isothiocyante (BITC), and phenethyl isothiocyanate (PEITC) showed the inhibition of premature death caused by LP-BM5 retrovirus infection, while indolo[3,2-b] carbazole (ICZ) and indole-3-carbinol (I3C) did not delay the progress of the LP-BM5 retrovirus to murine AIDS. Inhibition of premature death by BITC, PEITC, and SUL could be explained by restoration of the immune system and down regulation of free radicals. Dysfunction of T and B cell mitogenesis caused by retrovirus infection in primary cultured splenocytes has been partially recovered with administration of BITC, PEITC, and SUL. There was a shift from imbalanced cytokine production (increased Th2 and decreased Th1 cell cytokine production) into balanced Th1/Th2 cell secretion of cytokines under administration of these ITCs during the development of murine AIDS. Hepatic vitamin E level was significantly restored by administration of these ITCs, in accordance with reduced hepatic lipid peroxidation levels. This study suggests that certain types of ITCs have beneficial effects in preventing premature death during progression to murine AIDS by restoration of immune dysfunction and removal of excessive free radicals, implying that selective usage of ITCs would be helpful in retarding the progression from HIV infection to AIDS.
Files in This Item:
T201103298.pdf Download
DOI
10.1271/bbb.100840J
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94154
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