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Isolation of a Klebsiella pneumoniae isolate of sequence type 258 producing KPC-2 carbapenemase in Korea

Authors
 Kyoung Ho Roh ; Chang Kyu Lee ; Kyungwon Lee ; Dongeun Yong ; Wonkeun Song ; Jang Wook Sohn 
Citation
 Korean Journal of Laboratory Medicine, Vol.31(4) : 298~301, 2011 
Journal Title
 Korean Journal of Laboratory Medicine 
ISSN
 1598-6535 
Issue Date
2011
Abstract
Carbapenem-resistant Klebsiella pneumoniae isolates producing K. pneumoniae carbapenemases (KPC) were first reported in the USA in 2001, and since then, this infection has been reported in Europe, Israel, South America, and China. In Korea, the first KPC-2-producing K. pneumoniae sequence type (ST) 11 strain was detected in 2010. We report the case of a patient with a urinary tract infection caused by KPC-2-producing K. pneumoniae. This is the second report of a KPC-2-producing K. pneumoniae infection in Korea, but the multilocus sequence type was ST258. The KPC-2-producing isolate was resistant to all tested β-lactams (including imipenem and meropenem), amikacin, tobramycin, ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole, but was susceptible to gentamicin, colistin, polymyxin B, and tigecycline. The KPC-2-producing isolate was negative to phenotypic extended-spectrum β-lactamase (ESBL) and AmpC detection tests and positive to modified Hodge test and carbapenemase inhibition test with aminophenylboronic acid.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94150
DOI
10.3343/kjlm.2011.31.4.298
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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