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Lithospermic acid B protects β-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1.

Authors
 Byung-Wan Lee  ;  Sung Wan Chun  ;  Hyun Chul Lee  ;  Bong-Soo Cha  ;  Eun Seok Kang  ;  Yongho Lee  ;  Soo Hyun Kim 
Citation
 Toxicology and Applied Pharmacology, Vol.252(1) : 47-54, 2011 
Journal Title
 Toxicology and Applied Pharmacology 
ISSN
 0041-008X 
Issue Date
2011
Abstract
Lithospermic acid B (LAB) has been reported to protect OLETF rats, an established type 2 diabetic animal model, from the development of diabetes-related vascular complications. We investigated whether magnesium lithospermate B (LAB) has a protective role under cytokine-induced apoptosis in INS-1 cells in vitro and whether it slows the development of diabetes in OLETF rats in vivo. Pretreatment with 50 μM LAB significantly reduced the 1000 U/mL INF-γ and 100 U/mL IL-1β-induced INS-1 cell death. LAB significantly alleviated cytokine-induced phosphorylations of p38 and JNK in accordance with a decrease in cleaved caspase-3 activity in beta-cells. LAB also protected against the cytokine-induced caspase-3 apoptotic pathway via significant activation of Nrf2-HO (heme-oxygenase)-1 and Sirt1 expression. OLETF rats treated with 40 mg/kg/day LAB showed a significant improvement in glucose tolerance compared to untreated OLETF control rats in vivo. Our results suggest that the cytoprotective effects of LAB on pancreatic β-cells are related with both alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94144
DOI
10.1016/j.taap.2011.01.018
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강은석(Kang, Eun Seok) ; 김수혁(Kim, Soo Hyuk) ; 이병완(Lee, Byung Wan) ; 이용호(Lee, Yong Ho) ; 이현철(Lee, Hyun Chul) ; 전성완(Chun, Sung Wan) ; 차봉수(Cha, Bong Soo)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0041008X11000354
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