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Low serum vitamin D is associated with high risk of diabetes in Korean adults

Authors
 Han Seok Choi  ;  Kyoung-Ah Kim  ;  Chi-Yeon Lim  ;  Sang Youl Rhee  ;  You-Cheol Hwang  ;  Kyoung Min Kim  ;  Kwang Joon Kim  ;  Yumie Rhee  ;  Sung-Kil Lim 
Citation
 JOURNAL OF NUTRITION, Vol.141(8) : 1524-1528, 2011 
Journal Title
JOURNAL OF NUTRITION
ISSN
 0022-3166 
Issue Date
2011
MeSH
Adult ; Cross-Sectional Studies ; Diabetes Mellitus/blood* ; Female ; Humans ; Insulin Resistance ; Male ; Middle Aged ; Republic of Korea ; RiskFactors ; Vitamin D/blood*
Abstract
Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations <25, 25 to <50, and 50 to <75 nmol/L, respectively, after multiple adjustments (P-trend < 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = -0.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.
Files in This Item:
T201103286.pdf Download
DOI
10.3945/jn.111.139121.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Min(김경민)
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94141
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