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Low serum vitamin D is associated with high risk of diabetes in Korean adults

DC Field Value Language
dc.contributor.author김경민-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author김광준-
dc.date.accessioned2014-12-20T17:11:51Z-
dc.date.available2014-12-20T17:11:51Z-
dc.date.issued2011-
dc.identifier.issn0022-3166-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94141-
dc.description.abstractVitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations <25, 25 to <50, and 50 to <75 nmol/L, respectively, after multiple adjustments (P-trend < 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = -0.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJOURNAL OF NUTRITION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiabetes Mellitus/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRiskFactors-
dc.subject.MESHVitamin D/blood*-
dc.titleLow serum vitamin D is associated with high risk of diabetes in Korean adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHan Seok Choi-
dc.contributor.googleauthorKyoung-Ah Kim-
dc.contributor.googleauthorChi-Yeon Lim-
dc.contributor.googleauthorSang Youl Rhee-
dc.contributor.googleauthorYou-Cheol Hwang-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorSung-Kil Lim-
dc.identifier.doi10.3945/jn.111.139121.-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00295-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ01648-
dc.identifier.eissn1541-6100-
dc.identifier.pmid21697301-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.affiliatedAuthorKim, Kyung Min-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.rights.accessRightsfree-
dc.citation.volume141-
dc.citation.number8-
dc.citation.startPage1524-
dc.citation.endPage1528-
dc.identifier.bibliographicCitationJOURNAL OF NUTRITION, Vol.141(8) : 1524-1528, 2011-
dc.identifier.rimsid27267-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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