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Low serum vitamin D is associated with high risk of diabetes in Korean adults
DC Field | Value | Language |
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dc.contributor.author | 김경민 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2014-12-20T17:11:51Z | - |
dc.date.available | 2014-12-20T17:11:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0022-3166 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94141 | - |
dc.description.abstract | Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations <25, 25 to <50, and 50 to <75 nmol/L, respectively, after multiple adjustments (P-trend < 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = -0.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Diabetes Mellitus/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | RiskFactors | - |
dc.subject.MESH | Vitamin D/blood* | - |
dc.title | Low serum vitamin D is associated with high risk of diabetes in Korean adults | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Han Seok Choi | - |
dc.contributor.googleauthor | Kyoung-Ah Kim | - |
dc.contributor.googleauthor | Chi-Yeon Lim | - |
dc.contributor.googleauthor | Sang Youl Rhee | - |
dc.contributor.googleauthor | You-Cheol Hwang | - |
dc.contributor.googleauthor | Kyoung Min Kim | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.identifier.doi | 10.3945/jn.111.139121. | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00295 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J01648 | - |
dc.identifier.eissn | 1541-6100 | - |
dc.identifier.pmid | 21697301 | - |
dc.contributor.alternativeName | Kim, Kyung Min | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Min | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 141 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1524 | - |
dc.citation.endPage | 1528 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITION, Vol.141(8) : 1524-1528, 2011 | - |
dc.identifier.rimsid | 27267 | - |
dc.type.rims | ART | - |
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