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Mid-life and late-life vascular risk factors and dementia in Korean men and women

Authors
 H. Kimm  ;  P.H. Lee  ;  Y.J. Shin  ;  K.S. Park  ;  J. Jo  ;  Y. Lee  ;  H.C. Kang  ;  S.H. Jee 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.52(3) : 117-122, 2011 
Journal Title
ARCHIVES OF GERONTOLOGY AND GERIATRICS
ISSN
 0167-4943 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking/epidemiology ; Cholesterol/blood ; Comorbidity ; Dementia,Vascular/epidemiology* ; Dementia,Vascular/etiology* ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hypertension/epidemiology ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea/epidemiology ; RiskFactors ; Smoking/epidemiology
Keywords
Vascular dementia ; Alzheimer's disease ; Diabetes ; Cohort study
Abstract
Dementia is one of the most important neurological disorders in the elderly population. The significance of vascular risk factors for dementia remains controversial. This study aimed to determine the effects of vascular risk factors, such as blood pressure, diabetes and smoking in the mid-life or the late-life on dementia risk. The data in this prospective cohort study came from 3252 dementia events occurring over 14 years among 848,505 Koreans aged 40-95 years insured by the National Health Insurance Corporation who had a biennial medical evaluation during 1992-1995. Data on clinical dementia during the period 1993-2006 were examined in relation to vascular risk factors. The age adjusted incidence per 100,000 was 31.9 for men and 45.0 for women, respectively. In multivariate Cox proportional hazard models, diabetes increased the risk of either dementia in Alzheimer's disease or vascular dementia in men and women, controlling for age, hypertension, total cholesterol, alcohol drinking, and smoking. Hypertension also increased vascular dementia in both men [Hazard ratio (HR)=2.6, 95% confidence interval (CI)=1.7-3.8] and women (HR=2.3, 95%CI=1.6-3.3). The association of hypertension or diabetes on risk of vascular dementia, however, among the group aged older than 65 was attenuated but remained as significant in men. There was no interaction between hypertension and diabetes on the risk of dementia. This study demonstrates that diabetes and hypertension increased the risk of vascular dementia. Treatment for these risk factors may reduce the risk of vascular dementia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167494310002268
DOI
10.1016/j.archger.2010.09.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kang, Hee Cheol(강희철) ORCID logo https://orcid.org/0000-0002-0309-7448
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Park, Kwang Shik(박광식)
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94134
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