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Neurotrophin-3-Over-Expressing Mesenchymal Stem Cell Transplantation Improves Functional Recovery and Axonal Outgrowth in a Rat Model of Spinal Cord Injury

Authors
 Kyung Hee Lee  ;  Jin soo Oh  ;  Keung Nyun Kim  ;  Do Heum Yoon  ;  William A. Pennant  ;  Bae Hwan Lee  ;  Yoon Ha 
Citation
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학), Vol.8(5) : 477-481, 2011 
Journal Title
 Tissue Engineering and Regenerative Medicine  (조직공학과 재생의학) 
ISSN
 1738-2696 
Issue Date
2011
Abstract
We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94116
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김긍년(Kim, Keung Nyun) ; 오진수(Oh, Jin Soo) ; 윤도흠(Yoon, Do Heum) ; 이배환(Lee, Bae Hwan) ; 하윤(Ha, Yoon)
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