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Neurotrophin-3-Over-Expressing Mesenchymal Stem Cell Transplantation Improves Functional Recovery and Axonal Outgrowth in a Rat Model of Spinal Cord Injury
- Authors
- Kyung Hee Lee ; Jin soo Oh ; Yoon Ha ; Bae Hwan Lee ; William A. Pennant ; Do Heum Yoon ; Keung Nyun Kim
- Citation
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.8(5) : 477-481, 2011
- Journal Title
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학)
- ISSN
- 1738-2696
- Issue Date
- 2011
- Keywords
- spinal cord injury ; human mesenchymal stem cell ; neurotrophin-3 ; transplantation
- Abstract
- We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells
(NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury.
We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function,
axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a
useful strategy for treatment of spinal cord injury
- Files in This Item:
- T201103267.pdf Download
- Appears in Collections:
- 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
- Yonsei Authors
-
Kim, Keung Nyun(김긍년)
Oh, Jin Soo(오진수)
Yoon, Do Heum(윤도흠)
https://orcid.org/0000-0003-1452-5724
Lee, Bae Hwan(이배환) https://orcid.org/0000-0003-4719-9021
Ha, Yoon(하윤)
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