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소화기질환에서 줄기세포 치료의 현재와 미래 ; 소화기질환에서의 줄기세포를 이용한 임상연구와 줄기세포 치료의 미래

Other Titles
 Clinical Trials with Stem Cells in Digestive Diseases and Future Perspectives 
Authors
 Tae Il Kim 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.58(3) : 139~143, 2011 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2011
Abstract
Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the near future. Among refractory digestive diseases, Crohn`s disease and liver cirrhosis may be two main diseases where stem cell therapy can be applied for anti-inflammation and regeneration of tissue. Currently, with respect to these two diseases, clinical trials using hematopoietic stem cells and mesenchymal stem cells from bone marrow or adipose tissue have shown some evidence of clinical benefits to immune modulation, suppression of inflammation and regeneration of functional cells. However, for the development of practical stem cell therapy, we need more data on underlying mechanisms, effective subpopulation of stem cells and its sources, and effective parameters for monitoring and estimation. With technical advances, the research on embryonic and induced pluripotent stem cells will also contribute to the new therapeutic strategies for digestive regenerative medicine. In the future, a variety of stem cell therapies may be therapeutic options for refractory digestive diseases, but many technical challenges remain to be solved
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93951
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2944377
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