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Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia

Authors
 Jae-Hyun Kwon  ;  Young-Han Kim  ;  Ja-Young Kwon  ;  Yong-Won Park 
Citation
 Journal of Perinatal Medicine, Vol.39(5) : 507-513, 2011 
Journal Title
 Journal of Perinatal Medicine 
ISSN
 0300-5577 
Issue Date
2011
Abstract
BACKGROUND: We determined serum endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) concentrations and the esRAGE/sRAGE ratio in normal pregnancy and preeclampsia because esRAGE and sRAGE have been negatively linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia. METHOD: Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay. RESULTS: There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1(st) and 3(rd) trimester in normal pregnancy (P=0.007 and P=0.003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (P=0.005 and P<0.001). CONCLUSIONS: Maternal serum esRAGE concentration and esRAGE/sRAGE ratio (1) gradually decrease with gestational age in normal pregnancy; and (2) are higher in patients with preeclampsia than healthy pregnant controls, significantly. Serum esRAGE and esRAGE/sRAGE ratio might be associated with preeclampsia.
Full Text
http://www.degruyter.com/view/j/jpme.2011.39.issue-5/jpm.2011.055/jpm.2011.055.xml
DOI
10.1515/jpm.2011.055
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kwon, Jae Hyun(권재현)
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93889
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