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Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia

DC FieldValueLanguage
dc.contributor.author권자영-
dc.contributor.author권재현-
dc.contributor.author김영한-
dc.contributor.author박용원-
dc.date.accessioned2014-12-20T17:03:45Z-
dc.date.available2014-12-20T17:03:45Z-
dc.date.issued2011-
dc.identifier.issn0300-5577-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93889-
dc.description.abstractBACKGROUND: We determined serum endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) concentrations and the esRAGE/sRAGE ratio in normal pregnancy and preeclampsia because esRAGE and sRAGE have been negatively linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia. METHOD: Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay. RESULTS: There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1(st) and 3(rd) trimester in normal pregnancy (P=0.007 and P=0.003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (P=0.005 and P<0.001). CONCLUSIONS: Maternal serum esRAGE concentration and esRAGE/sRAGE ratio (1) gradually decrease with gestational age in normal pregnancy; and (2) are higher in patients with preeclampsia than healthy pregnant controls, significantly. Serum esRAGE and esRAGE/sRAGE ratio might be associated with preeclampsia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent507~513-
dc.relation.isPartOfJournal of Perinatal Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHPre-Eclampsia/blood*-
dc.subject.MESHPregnancy/blood*-
dc.subject.MESHPregnancy Trimester, First/blood-
dc.subject.MESHPregnancy Trimester, Third/blood-
dc.subject.MESHReceptor for Advanced Glycation End Products-
dc.subject.MESHReceptors, Immunologic/blood*-
dc.subject.MESHReference Values-
dc.subject.MESHSolubility-
dc.titleClinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorJae-Hyun Kwon-
dc.contributor.googleauthorYoung-Han Kim-
dc.contributor.googleauthorJa-Young Kwon-
dc.contributor.googleauthorYong-Won Park-
dc.identifier.doi10.1515/jpm.2011.055-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00246-
dc.contributor.localIdA00248-
dc.contributor.localIdA00730-
dc.contributor.localIdA01581-
dc.relation.journalcodeJ01693-
dc.identifier.pmid21767223-
dc.identifier.urlhttp://www.degruyter.com/view/j/jpme.2011.39.issue-5/jpm.2011.055/jpm.2011.055.xml-
dc.subject.keywordesRAGE-
dc.subject.keywordpreeclampsia-
dc.subject.keywordsRAGE-
dc.contributor.alternativeNameKwon, Ja Young-
dc.contributor.alternativeNameKwon, Jae Hyun-
dc.contributor.alternativeNameKim, Young Han-
dc.contributor.alternativeNamePark, Yong Won-
dc.contributor.affiliatedAuthorKwon, Ja Young-
dc.contributor.affiliatedAuthorKwon, Jae Hyun-
dc.contributor.affiliatedAuthorKim, Young Han-
dc.contributor.affiliatedAuthorPark, Yong Won-
dc.rights.accessRightsnot free-
dc.citation.volume39-
dc.citation.number5-
dc.citation.startPage507-
dc.citation.endPage513-
dc.identifier.bibliographicCitationJournal of Perinatal Medicine, Vol.39(5) : 507-513, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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