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Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia

Authors
 Nam Su Ku  ;  Sang Hoon Han  ;  Chang Oh Kim  ;  Ji-Hyeon Baek  ;  Su Jin Jeong  ;  Sung Joon Jin  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim 
Citation
 SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, Vol.43(10) : 792-797, 2011 
Journal Title
 SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 
ISSN
 0036-5548 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/microbiology ; Bacteremia/mortality* ; Burkholderia Infections/drug therapy ; Burkholderia Infections/microbiology ; Burkholderia Infections/mortality* ; Burkholderia cepacia complex* ; Diabetes Mellitus/microbiology ; Female ; Hospitals ; Humans ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors
Abstract
BACKGROUND: Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B. cepacia complex has been associated with increased morbidity and mortality in intensive care unit patients. However, in our literature search, we could not find studies on risk factors for mortality in patients with B. cepacia complex bacteraemia. Therefore, we investigated risk factors for mortality in B. cepacia complex bacteraemia. METHODS: Clinical characteristics and laboratory parameters of 27 patients with 1 or more blood cultures positive for B. cepacia complex from January 2006 to October 2010 in Severance Hospital, Yonsei University College of Medicine, Korea were retrospectively analyzed. The main outcome measure was overall 28-day mortality. Appropriate initial empirical antimicrobial use was defined as administration of agent(s) to which the organism was susceptible within 24 h of obtaining blood for culture. RESULTS: The overall 28-day mortality rate was 41% (11/27). In univariate analysis, underlying diabetes mellitus (p = 0.033), inappropriate initial empirical antimicrobial therapy (p = 0.033), and an elevated Sequential Organ Failure Assessment (SOFA) score (p = 0.002) were significantly associated with mortality. In multivariate analysis, inappropriate initial empirical antimicrobial therapy and an elevated SOFA score were independent risk factors for increased mortality (p = 0.032 and p = 0.028, respectively). CONCLUSIONS: An elevated SOFA score and inappropriate initial empirical antimicrobial therapy were significantly associated with adverse outcome in patients with B. cepacia complex bacteraemia.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00365548.2011.589076
DOI
10.3109/00365548.2011.589076
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jin, Sung Joon(진성준)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93873
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