Cited 58 times in
Comparison of diffusion-weighted MRI and MR volumetry in the evaluation of early treatment outcomes after preoperative chemoradiotherapy for locally advanced rectal cancer
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 금기창 | - |
dc.contributor.author | 김경아 | - |
dc.contributor.author | 김기황 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 김영철 | - |
dc.date.accessioned | 2014-12-20T17:02:51Z | - |
dc.date.available | 2014-12-20T17:02:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93861 | - |
dc.description.abstract | PURPOSE: To compare diffusion-weighted imaging (DWI) and magnetic resonance (MR) volumetry for predicting treatment outcomes of locally advanced rectal cancers with preoperative chemoradiotherapy (CRT). MATERIALS AND METHODS: This prospective study was approved by our Institutional Review Board. Thirty-four patients underwent three MR examinations: pre-CRT (before CRT), early CRT (2 weeks after CRT initiation), and post-CRT (before surgery). The tumor apparent diffusion coefficient (ADC), ADC increase rate, and volume reduction rate were compared between responders and nonresponders using three reference standards: downstaging, modified Response Evaluation Criteria in Solid Tumors (mRECIST), and tumor regression grade (TRG). For DWI and volumetry, differences between responders and nonresponders were assessed by receiver operating characteristic analysis. RESULTS: The median early tumor volume reduction rate of responders, subgrouped by downstaging and mRECIST (47.97% and 53.97%, respectively), was significantly higher than that of nonresponders (20.94% and 20.36%; P = 0.0024 and 0.0001, respectively), but there were no significant differences in pre-CRT ADC and early ADC increase rate using all references. When using the downstaging and mRECIST, the diagnostic performance of early tumor volume reduction rate (Az = 0.81 and 0.94, respectively) was higher than that of pre-CRT ADC (Az = 0.55 and 0.62; P = 0.033 and 0.007) and early ADC increase rate (Az = 0.58 and 0.64; P = 0.055 and 0.01) for predicting the treatment outcome. For TRG, there were no significant differences between DWI and volumetry. CONCLUSION: Early tumor volume reduction rate at the second week after CRT initiation may be a better indicator than DWI based on the mean ADC measurements for predicting CRT treatment outcome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 570~576 | - |
dc.relation.isPartOf | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Algorithms* | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant/methods* | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Enhancement/methods | - |
dc.subject.MESH | Image Interpretation, Computer-Assisted/methods* | - |
dc.subject.MESH | Imaging, Three-Dimensional/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Outcome Assessment (Health Care)/methods | - |
dc.subject.MESH | Preoperative Care/methods | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Rectal Neoplasms/pathology* | - |
dc.subject.MESH | Rectal Neoplasms/therapy* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Comparison of diffusion-weighted MRI and MR volumetry in the evaluation of early treatment outcomes after preoperative chemoradiotherapy for locally advanced rectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Young Chul Kim | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Kyung Ah Kim | - |
dc.contributor.googleauthor | Sungmin Myoung | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Jinsuk Suh | - |
dc.contributor.googleauthor | Ki Whang Kim | - |
dc.identifier.doi | 10.1002/jmri.22696 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00345 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A00728 | - |
dc.contributor.localId | A00301 | - |
dc.relation.journalcode | J01567 | - |
dc.identifier.eissn | 1522-2586 | - |
dc.identifier.pmid | 21751285 | - |
dc.identifier.url | http://dx.doi.org/10.1002/jmri.22696 | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Lim, Joon Seok | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Kyung Ah | - |
dc.contributor.alternativeName | Kim, Ki Whang | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Kim, Young Chul | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Shin, Sang Joon | - |
dc.contributor.affiliatedAuthor | Lim, Joon Seok | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Ki Whang | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Young Chul | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Ah | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 570 | - |
dc.citation.endPage | 576 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.34(3) : 570-576, 2011 | - |
dc.identifier.rimsid | 28510 | - |
dc.type.rims | ART | - |
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