Cited 6 times in
The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival
DC Field | Value | Language |
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dc.contributor.author | 허규하 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 방우휘 | - |
dc.contributor.author | 서활 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 주동진 | - |
dc.date.accessioned | 2014-12-20T17:01:43Z | - |
dc.date.available | 2014-12-20T17:01:43Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0022-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93825 | - |
dc.description.abstract | BACKGROUND: AEB071 (sotrastaurin) is a specific inhibitor of protein kinase C that prevents T-cell activation. Our previous study demonstrated that AEB071 monotherapy could prevent acute cardiac allograft rejection in rats. Herein, we investigated the effects of AEB071 combined with various doses of tacrolimus (Tac) on the allograft rejection and survival in a rat heart transplantation model. MATERIALS AND METHODS: Heterotopic cardiac transplantation from Brown-Norway to Lewis rats was performed. Cardiac allograft survival was assessed by monitoring heartbeats in six recipients of each experimental group. Another four recipient rats were selectively sacrificed in each group at d 7 post-transplantation for histologic examination. Serum transaminases, blood urea nitrogen, and creatinine concentrations were measured. RESULTS: AEB071 monotherapy prolonged allograft mean survival time (MST) compared with the untreated control group. Also a combination of AEB071 and Tac prolonged MST compared with monotherapy groups with higher dose of Tac. In the cardiac graft histology, AEB071 combined with Tac 0.6 mg/kg/d significantly decreased the rejection grade as indicative of decreased inflammatory cell infiltration into the graft. No experimental group was found with any abnormal histologic or serologic evidence of liver and kidney toxicity. CONCLUSION: AEB071 combined with a smaller dosage of Tac may be clinically possible to establish calcineurin inhibitor (CNI) minimization protocol in solid organ transplantation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e131~e137 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Graft Rejection/drug therapy* | - |
dc.subject.MESH | Graft Survival/drug effects* | - |
dc.subject.MESH | Heart Transplantation* | - |
dc.subject.MESH | Immunosuppressive Agents/pharmacology | - |
dc.subject.MESH | Kidney/physiology | - |
dc.subject.MESH | Liver/physiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Protein Kinase Inhibitors/pharmacology | - |
dc.subject.MESH | Pyrroles/pharmacology* | - |
dc.subject.MESH | Quinazolines/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Inbred BN | - |
dc.subject.MESH | Rats, Inbred Lew | - |
dc.subject.MESH | Tacrolimus/pharmacology* | - |
dc.subject.MESH | Transplantation, Heterotopic | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | The effects of AEB071 (sotrastaurin) with tacrolimus on rat heterotopic cardiac allograft rejection and survival | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Yu Hui Fang | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.identifier.doi | 10.1016/j.jss.2011.06.039 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01789 | - |
dc.contributor.localId | A01924 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J01763 | - |
dc.identifier.eissn | 1095-8673 | - |
dc.identifier.pmid | 21816421 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022480411005890 | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Fang, Yu Hui | - |
dc.contributor.alternativeName | Suh, Hwal | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Fang, Yu Hui | - |
dc.contributor.affiliatedAuthor | Suh, Hwal | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 171 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 131 | - |
dc.citation.endPage | 137 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL RESEARCH, Vol.171(1) : 131-137, 2011 | - |
dc.identifier.rimsid | 28491 | - |
dc.type.rims | ART | - |
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