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Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension.

 Woo-In Yang  ;  Sungha Park  ;  Jong-Chan Youn  ;  Nak Hoon Son  ;  Sang-Hak Lee  ;  Seok-Min Kang  ;  Yangsoo Jang 
 AMERICAN JOURNAL OF HYPERTENSION, Vol.24(11) : 1234-1238, 2011 
Journal Title
Issue Date
Adult ; Cardiovascular Diseases/physiopathology ; Endothelium, Vascular/physiopathology* ; Female ; Fingers/blood supply ; Humans ; Hyperemia/physiopathology* ; Hypertension/physiopathology* ; Male ; Manometry ; Middle Aged ; Pulsatile Flow/physiology*
BACKGROUND: Augmentation pressure has emerged as a surrogate marker for cardiovascular disease, and endothelial dysfunction has been proposed as related factor. However, the relationship between augmentation pressure and digital endothelial function has not yet been well defined. We investigated the relationship between augmentation pressure and digital reactive hyperemia (RH) in patients with hypertension using peripheral arterial tonometry (PAT), which is regarded as being representative of endothelial function. METHODS: One hundred hypertensive patients (64 males; mean age, 49 ± 12 years) without a history of taking antihypertensive medication were enrolled in this study. RESULTS: The mean augmentation pressure and augmentation index (AIx) normalized for a heart rate of 75 beats/min (AIx75) were 15 ± 8 mm Hg and 26 ± 11%, respectively. The mean RH-PAT index and log transformed PAT ratio were 2.24 ± 0.55 and 0.62 ± 0.30. There was an inverse relationship between the RH-PAT index and age, male sex, and body mass index. The log transformed PAT ratio also showed inverse relationship with age and male sex. The RH-PAT index and the log transformed PAT ratio showed no relationship with augmentation pressure or AIx75. In a multiple linear regression analysis, age, height, and central systolic BP demonstrated an independent association with augmentation pressure and AIx75. CONCLUSION: In patients with hypertension, the RH-PAT index determined using PAT was not associated with augmentation pressure or AIx75. Digital vascular function may be a less important factor for pressure augmentation in patients with hypertension.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Son, Nak Hoon(손낙훈)
Yang, Woo In(양우인)
Youn, Jong Chan(윤종찬)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
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